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SML1112

Sigma-Aldrich

Remodelin 氢溴酸盐

≥98% (HPLC)

别名:

4-[2-（2-环戊基茚基肼基）-4-噻唑基]-苄腈 氢溴酸盐

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About This Item

经验公式（希尔记法）:
C15H14N4S · HBr
CAS号:
949912-58-7
分子量:
363.28
MDL编号:
MFCD28137688
UNSPSC代码:
12352200
PubChem化学物质编号:
329825653
NACRES:
NA.77

质量水平

100

方案

≥98% (HPLC)

表单

powder

储存条件

desiccated

颜色

white to beige

溶解性

DMSO: 20 mg/mL, clear

储存温度

2-8°C

SMILES字符串

N#CC(C=C1)=CC=C1C2=CSC(NN=C3CCCC3)=N2.Br

InChI

1S/C15H14N4S.BrH/c16-9-11-5-7-12(8-6-11)14-10-20-15(17-14)19-18-13-3-1-2-4-13;/h5-8,10H,1-4H2,(H,17,19);1H

InChI key

XNWBCMSPDCSWSD-UHFFFAOYSA-N

生化/生理作用

Remodelin是参与到稳定微管的核仁N-乙酰转移酶NAT10的一种抑制剂。
Remodelin是参与到稳定微管的核仁N-乙酰转移酶NAT10的一种抑制剂。Remodelin已被发现可纠正与早衰相关的细胞缺陷、改善核的形状并减少被认为与层粘连蛋白A基因突变相关的DNA损伤。尽管该机制仍在研究中，但似乎也涉及到微管的稳定性。在椎板细胞中对Remodelin对NAT10活性的抑制似乎导致微管锚定减少，从而使椎板细胞的核形状正常化。Remodelin应该可作为一种有效的工具，用于研究NAT10如何影响核结构、其与椎板病和衰老的关系及可能的治疗，以及它在各种软组织肉瘤中所发现的过度表达。

特点和优势

这种化合物是基因调控研究的特色产品。点击此处发现更多特色基因调控产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。

象形图

Exclamation mark
GHS07

警示用语：

Warning

危险声明

H302

危险分类

Acute Tox. 4 Oral

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000284033
0000284032
0000265905
0000175894
0000175893

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Kevin Tsai et al.
Cell host & microbe, 28(2), 306-312 (2020-06-14)
Epitranscriptomic RNA modifications, including methylation of adenine and cytidine residues, are now recognized as key regulators of both cellular and viral mRNA function. Moreover, acetylation of the N4 position of cytidine (ac4C) was recently reported to increase the translation and

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