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Merck
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主要文件

317240

Sigma-Aldrich

盐酸二甲双胍

≥97% (titration), solid, AMPK signaling activator, Calbiochem®

别名:

盐酸二甲双胍

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About This Item

经验公式（希尔记法）:
C4H11N5 · xHCl
CAS号:
1115-70-4
分子量:
129.16 (free base basis)
MDL號碼:
MFCD00012582
分類程式碼代碼:
12352200
NACRES:
NA.77
价格与库存信息目前不能提供

产品名称

盐酸二甲双胍, An antihyperglycemic agent that lowers blood glucose levels without stimulating insulin secretion, promoting weight gain or causing hypoglycemia.

品質等級

100

化驗

≥97% (titration)

形狀

solid

製造商／商標名

Calbiochem®

儲存條件

OK to freeze
desiccated (hygroscopic)

顏色

white

溶解度

water: 50 mg/mL

運輸包裝

ambient

儲存溫度

10-30°C

SMILES 字串

Cl.N(C)(C)C(=N\C(=N\[H])\N)N

InChI

1S/C4H11N5.ClH/c1-9(2)4(7)8-3(5)6;/h1-2H3,(H5,5,6,7,8);1H

InChI 密鑰

OETHQSJEHLVLGH-UHFFFAOYSA-N

一般說明

一种通过降低肝脏葡萄糖输出而起作用的抗高血糖药。不会刺激胰岛素分泌，促进体重增加或引起低血糖症。据报道刺激AMP激活的蛋白激酶（AMPK），导致乙酰辅酶A羧化酶（ACC）活性降低和脂肪酸氧化诱导。
一种降低血葡萄糖水平而不刺激胰岛素分泌、促进体重增加或引起低血糖症的抗高血糖药。据报道刺激AMP激活的蛋白激酶（AMPK），导致乙酰辅酶A羧化酶（ACC）活性降低和脂肪酸氧化诱导。

生化／生理作用

主要靶标
AMP激活的蛋白激酶（AMPK）
产物不与ATP竞争。
可逆：否
细胞渗透性：否

包裝

用惰性气体包装

警告

毒性：刺激性（B）

重構

复溶后，等分并冷冻保存（-20°C）。储备溶液在-20°C下可稳定保存至多6个月。

其他說明

Cleasby, M.E., et al. 2004.Diabetes53, 3258.
Klein, J., et al. 2004.J. Endocrinol.183, 299.
Zhou, G., et al. 2001.J. Clin. Invest.108, 1167.
Lin, H.Z., et al. 2000.Nat. Med.6, 998.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

象形圖

Exclamation mark
GHS07

訊號詞

Warning

危險聲明

H302,H319

危險分類

Acute Tox. 4 Oral - Eye Irrit. 2

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 1

閃點（°F）

Not applicable

閃點（°C）

Not applicable

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Questions

1–2 of 2 Questions  

  1. What is the solubility of Metformin (Cat#317240) in DMSO?

    1 answer

    1. The substance dissolves in DMSO at concentrations of up to 8 mg/ml.

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  2. is metformin accociated with paracitic worms?

    1 answer

    1. There have been studies published regarding the efficacy of Metformin against various parasites. Please see the link below to review one such study of Echinococcisis. Note that this product is intended for research use only and is not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5321462/

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