所有图片(1)

文件

SML1072

GSK-LSD1

Name: GSK-LSD1
Brand: SIGMA

≥98% (HPLC)

别名:

GSK-LSD1（反式外消旋）二盐酸盐, rel-N-[（1R，2S）-2-苯基环丙基] -4-哌啶胺盐酸盐（1：2）

登录查看公司和协议定价

所有图片(1)

About This Item

经验公式（希尔记法）:

C₁₄H₂₀N₂ · 2HCl

CAS号:

1431368-48-7

分子量:

289.24

分類程式碼代碼:

51111800

PubChem物質ID:

329825454

NACRES:

NA.77

推荐产品

Slide 1 of 10

1 of 10

Sigma-Aldrich

P8511

反式 -2-苯环丙胺盐酸盐

Sigma-Aldrich

489479

LSD1 Inhibitor IV, RN-1, 2HCl

Sigma-Aldrich

SML0778

UNC1999

Sigma-Aldrich

SML0709

GSK-J1

Sigma-Aldrich

489477

LSD1抑制剂II，S2101

Sigma-Aldrich

SML0766

GSK343

Sigma-Aldrich

SML0701

GSK-J4

Sigma-Aldrich

A7655

阿替洛尔

Sigma-Aldrich

O3008

油酸-白蛋白来源于牛血清

Sigma-Aldrich

D0899

地西泮

品質等級

100

化驗

≥98% (HPLC)

形狀

powder

顏色

white to beige

溶解度

H₂O: 20 mg/mL, clear

儲存溫度

2-8°C

SMILES 字串

C1(N[C@@H]2C[C@H]2C3=CC=CC=C3)CCNCC1

InChI

1S/C14H20N2/c1-2-4-11(5-3-1)13-10-14(13)16-12-6-8-15-9-7-12/h1-5,12-16H,6-10H2/t13-,14+/m0/s1

InChI 密鑰

BASFYRLYJAZPPL-UONOGXRCSA-N

應用

GSK-LSD1已用作小鼠中的赖氨酸特异性脱甲基酶 1（LSD1）抑制剂，用于研究败血症诱导的死亡率。它还被用作抑制剂，用于研究苯乙肼激活人类免疫缺陷病毒（HIV）潜伏期是否由 LSD1 引起。

生化／生理作用

GSK-LSD1 是赖氨酸特异性脱甲基酶 1（LSD1）的有效选择性抑制剂。GSK-LSD1 通过改变基因表达模式有效抑制不同癌细胞系的增殖。有关完整特征描述的详细信息，请访问 Structural Genomics Consortium（SGC）网站上的 GSK-LSD1 探针目录。

要了解用于表观遗传目标的其他 SGC 化学探针，请访问 sigma.com/sgc

特點和優勢

GSK-LSD1 是一种表观遗传化学探针，是与 Structural Genomics Consortium (SGC) 合作研发的。想要了解更多信息并查看其他SGC表观遗传探针，请访问sigma.com/SGC。

这种化合物是基因调控研究的特色产品。点击此处发现更多特色基因调控产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

分析证书(COA)

输入产品批号来搜索分析证书(COA) 。批号可以在产品标签上"批“ （Lot或Batch）字后找到。

已有该产品？

在文件库中查找您最近购买产品的文档。

访问文档库

其他客户在看

Slide 1 of 7

1 of 7

Sigma-Aldrich

SML0067

IOX1

Sigma-Aldrich

SML1133

SGC-CBP30

Sigma-Aldrich

SML0939

PFI-3

Sigma-Aldrich

SML1037

UNC0642

Sigma-Aldrich

SML0766

GSK343

Sigma-Aldrich

R6513

核糖核酸酶A 来源于牛胰腺

Millipore

E1014

Benzonase^®核酸酶

PKCα-LSD1-NF-κB-Signaling Cascade Is Crucial for Epigenetic Control of the Inflammatory Response

Kim D, et al.

Molecular Cell, 69(3), 398-411 (2018)

HIV-1 infection of microglial cells in a reconstituted humanized mouse model and identification of compounds that selectively reverse HIV latency

Llewellyn GN, et al.

Journal of Neurovirology, 1-12 (2017)

Patterns of transcription factor programs and immune pathway activation define four major subtypes of SCLC with distinct therapeutic vulnerabilities.

Carl M Gay et al.

Cancer cell, 39(3), 346-360 (2021-01-23)

Despite molecular and clinical heterogeneity, small cell lung cancer (SCLC) is treated as a single entity with predictably poor results. Using tumor expression data and non-negative matrix factorization, we identify four SCLC subtypes defined largely by differential expression of transcription

Scaffolding LSD1 Inhibitors Impair NK Cell Metabolism and Cytotoxic Function Through Depletion of Glutathione.

Cavan P Bailey et al.

Frontiers in immunology, 11, 2196-2196 (2020-10-13)

Cell therapies such as chimeric-antigen receptor (CAR) T-cells and NK cells are cutting-edge methods for treating cancer and other diseases. There is high interest in optimizing drug treatment regimens to best work together with emerging cell therapies, such as targeting

Lysine specific demethylase 1 inactivation enhances differentiation and promotes cytotoxic response when combined with all-trans retinoic acid in acute myeloid leukemia across subtypes.

Kimberly N Smitheman et al.

Haematologica, 104(6), 1156-1167 (2018-12-06)

Lysine specific demethylase 1 (LSD1) is a histone modifying enzyme that suppresses gene expression through demethylation of lysine 4 on histone H3. The anti-tumor activity of GSK2879552 and GSK-LSD1, potent, selective irreversible inactivators of LSD1, has previously been described. Inhibition

查看所有相关文献

商品

Discover Bioactive Small Molecules for Gene Regulation

We offer a variety of small molecule research tools, such as transcription factor modulators, inhibitors of chromatin modifying enzymes, and agonists/antagonists for target identification and validation in gene regulation research; a selection of these research tools is shown below.

Discover Bioactive Small Molecules for Gene Regulation

We offer a variety of small molecule research tools, such as transcription factor modulators, inhibitors of chromatin modifying enzymes, and agonists/antagonists for target identification and validation in gene regulation research; a selection of these research tools is shown below.

Discover Bioactive Small Molecules for Gene Regulation

We offer a variety of small molecule research tools, such as transcription factor modulators, inhibitors of chromatin modifying enzymes, and agonists/antagonists for target identification and validation in gene regulation research; a selection of these research tools is shown below.

Discover Bioactive Small Molecules for Gene Regulation

We offer a variety of small molecule research tools, such as transcription factor modulators, inhibitors of chromatin modifying enzymes, and agonists/antagonists for target identification and validation in gene regulation research; a selection of these research tools is shown below.

我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系技术服务部门

文件

GSK-LSD1

≥98% (HPLC)

About This Item

推荐产品

属性

品質等級

化驗

形狀

顏色

溶解度

儲存溫度

SMILES 字串

InChI

InChI 密鑰

相关类别

说明

應用

生化／生理作用

特點和優勢

相关产品

相關產品

安全信息

儲存類別代碼

水污染物質分類（WGK）

閃點（°F）

閃點（°C）

文件

分析证书(COA)

已有该产品？

其他客户在看

同行评审论文

技术文章和实验方案

商品

技术服务