SML1209

OICR-9429

≥98% (HPLC)

• 别名: 6-Oxo-4-trifluoromethyl-1,6-dihydro-pyridine-3-carboxylic acid [4-(4-methyl-piperazin-1-yl)-3′-morpholin-4-ylmethyl-biphenyl-3-yl]-amide
• 经验公式（希尔记法）: C₂₉H₃₂F₃N₅O₃
• CAS号: 1801787-56-3
• 分子量: 555.59
• MDL编号: MFCD18364451
• UNSPSC代码: 12352200
• PubChem化学物质编号: 329825720
• NACRES: NA.77

属性

• 质量水平: 100
• 方案: ≥98% (HPLC)
• 表单: powder
• 颜色: white to light brown
• 溶解性: DMSO: 10 mg/mL, clear
• 储存温度: 2-8°C
• SMILES字符串: FC1=CN(C(=O)NC1=O)CC#C
• InChI: 1S/C7H5FN2O2/c1-2-3-10-4-5(8)6(11)9-7(10)12/h1,4H,3H2,(H,9,11,12)
• InChI key: GMCOGJQJFDQZCP-UHFFFAOYSA-N

说明

生化/生理作用

OICR-9429 is a cell penetrant, potent and selective antagonist of the interaction of WDR5 (WD repeat domain 5) with peptide regions of MLL and Histone 3 that potently binds to WDR5.

OICR-9429 is a cell penetrant, potent and selective antagonist of the interaction of WDR5 (WD repeat domain 5) with peptide regions of MLL and Histone 3 that potently binds to WDR5. OICR-9429 inhibits the interaction of WDR5 with MLL1 and RbBP5 in cells. For full characterization details, please see OICR-9429 on the Structural Genomics Consortium (SGC) website.

OICR-0547 is the negative control for the active probe, OICR-9429. To request a sample of the negative control from the SGC, click here.

To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc

特点和优势

OICR-9429 is an epigenetic chemical probe available through a partnership with the Structural Genomics Consortium (SGC). To learn more and view other SGC epigenetic probes, visit sigma.com/SGC.

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

其他说明

OICR-9429 has been expertly reviewed and recommended by the Chemical Probes Portal. For more information, please visit the OICR-9429 probe summary on the Chemical Probes Portal website.

安全信息

• 象形图: GHS07
• 警示用语：: Warning
• 危险声明: H315
• 预防措施声明: P264 - P280 - P302 + P352 - P332 + P313 - P362 + P364
• 危险分类: Skin Irrit. 2
• 储存分类代码: 11 - Combustible Solids
• WGK: WGK 3
• 闪点(°F): Not applicable
• 闪点(°C): Not applicable