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應用
2-D08已被用作小泛素样修饰物（SUMO）抑制剂。
生化／生理作用
2-D08是一种有效的细胞渗透性的SUMO化抑制剂，可阻断SUMO（小泛素样修饰物）从E2酶（Ubc9）硫酯缀合物向底物的转移。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
MG132?induced progerin clearance is mediated by autophagy activation and splicing regulation.
Harhouri K, et al.
EMBO Molecular Medicine (2017)
RAS GTPases are modified by SUMOylation.
Choi B H, et al.
Oncotarget, 9(4), 4440-4440 (2018)
Karim Harhouri et al.
EMBO molecular medicine, 9(9), 1294-1313 (2017-07-05)
Hutchinson-Gilford progeria syndrome (HGPS) is a lethal premature and accelerated aging disease caused by a de novo point mutation in LMNA encoding A-type lamins. Progerin, a truncated and toxic prelamin A issued from aberrant splicing, accumulates in HGPS cells' nuclei
Byeong Hyeok Choi et al.
Oncotarget, 9(4), 4440-4450 (2018-02-13)
RAS proteins are GTPases that participate in multiple signal cascades, regulating crucial cellular processes including cell survival, proliferation, differentiation, and autophagy. Mutations or deregulated activities of RAS are frequently the driving force for oncogenic transformation and tumorigenesis. Given the important
Pan Zhou et al.
Biochemical and biophysical research communications, 513(4), 1063-1069 (2019-04-24)
Acute myeloid leukemia (AML) is a heterogeneous clonal hematopoietic malignancy with poor survival and frequent relapse. Recently, a posttranslational modification of proteins with small ubiquitin-like modifiers (SUMO) has been notably implicated in a wide spectrum of diseases, especially cancers. Ubc9
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