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Merck
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文件

A7236

Sigma-Aldrich

漆树酸

别名:

2-羟基-6-十五烷基苯甲酸, 6-十五烷基水杨酸, 银杏酸

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About This Item

经验公式（希尔记法）:
C22H36O3
CAS号:
16611-84-0
分子量:
348.52
MDL號碼:
MFCD07368254
分類程式碼代碼:
12352106
PubChem物質ID:
329770923
NACRES:
NA.77

形狀

powder

儲存條件

protect from light

顏色

white to beige

溶解度

DMSO: ≥20 mg/mL

儲存溫度

−20°C

SMILES 字串

CCCCCCCCCCCCCCCc1cccc(O)c1C(O)=O

InChI

1S/C22H36O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-16-19-17-15-18-20(23)21(19)22(24)25/h15,17-18,23H,2-14,16H2,1H3,(H,24,25)

InChI 密鑰

ADFWQBGTDJIESE-UHFFFAOYSA-N

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應用

漆树酸已：
  • 用作组蛋白乙酰化酶(HAT)抑制剂，以研究其对大鼠皮层神经元的影响
  • 用作体外乙酰化试验的阳性对照
  • 用作乙酰化酶抑制剂，以研究其对转染人胚胎肾细胞的核糖核酸输出1 (Rae-1)蛋白乙酰化的影响

生化／生理作用

漆树酸是一种从腰果果壳中提取的天然生物活性化合物。它具有抗真菌、抗菌、抗白蚁和杀软体动物的活性。漆树酸作为一种治疗剂，可对抗肥胖、癌症、炎症疾病和氧化损伤。它作为各种酶的抑制剂，如脂氧合酶(LOX-1)、黄嘌呤氧化酶、核因子κ B (NFκB)激酶、酪氨酸酶和脲酶。
漆树酸是 HAT（组蛋白乙酰转移酶）抑制剂。

特點和優勢

这种化合物是基因调控研究的特色产品。点击此处发现更多特色基因调控产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

分析证书(COA)

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Mahadevappa Hemshekhar et al.
Basic & clinical pharmacology & toxicology, 110(2), 122-132 (2011-11-23)
Anacardic acid (AA) is a bioactive phytochemical found in nutshell of Anacardium occidentale. Chemically, it is a mixture of several closely related organic compounds, each consisting of salicylic acid substituted with an alkyl chain. The traditional Ayurveda depicts nutshell oil
Mingxi Li et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 877(30), 3885-3892 (2009-10-16)
Global histone modifications and their putative relevance to short and long term cellular programming have drawn substantial interest in the study of chromatin. Here we describe the use of reverse-phase liquid chromatography coupled to Linear Ion Trap-Fourier Transform Mass Spectrometry
ZhenHua Ni et al.
Respiratory research, 12, 47-47 (2011-04-15)
"Phosphatase and tensin homolog deleted on chromosome 10" (PTEN) is mostly considered to be a cancer-related gene, and has been suggested to be a new pathway of pathogenesis of asthma. The purpose of this study was to investigate the effects
B Devipriya et al.
Journal of molecular graphics & modelling, 34, 57-66 (2012-02-07)
A charge density analysis has been performed on gas phase and docked forms of anacardic acid molecule to understand its charge density distribution, electrostatic moments and the conformation in the active site of p300 enzyme. Here, we report the binding
Massimo Ghizzoni et al.
European journal of medicinal chemistry, 47(1), 337-344 (2011-11-22)
Histone acetyltransferases are important enzymes that regulate various cellular functions, such as epigenetic control of DNA transcription. Development of HAT inhibitors with high selectivity and potency will provide powerful mechanistic tools for the elucidation of the biological functions of HATs
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