所有图片(1)
About This Item
经验公式（希尔记法）:
C26H22N2O2
CAS号:
分子量:
394.47
MDL號碼:
分類程式碼代碼:
12352203
PubChem物質ID:
NACRES:
NA.77
推荐产品
品質等級
化驗
≥95% (HPLC)
形狀
solid
溶解度
DMSO: soluble
儲存溫度
−20°C
SMILES 字串
CC(NC(=O)c1ccccc1\N=C\c2c(O)ccc3ccccc23)c4ccccc4
InChI
1S/C26H22N2O2/c1-18(19-9-3-2-4-10-19)28-26(30)22-13-7-8-14-24(22)27-17-23-21-12-6-5-11-20(21)15-16-25(23)29/h2-18,29H,1H3,(H,28,30)/b27-17+
InChI 密鑰
UXJFDYIHRJGPFS-WPWMEQJKSA-N
基因資訊
human ... SIRT1(23411) , SIRT2(22933)
應用
用sirtinol处理HUVEC以研究转录因子Krüppel样因子2的诱导作用。4 Sirtinol可用于处理人胚肾细胞，以研究其对Werner综合征蛋白表达的影响。5
生化／生理作用
Sirtinol可在 体内抑制酵母Sir2p转录沉默活性， 体外抑制酵母Sir2p和人SIRT2脱乙酰酶活性。它可抑制血小板聚集的生理调节剂（如凝血酶和胶原蛋白），减弱细胞内Ca2+的释放并形成血栓素B2。它可以通过抑制cAMP磷酸二酯酶来增加cAMP的水平并抑制血小板的聚集。2 Sirtinol可降低人皮肤微血管内皮细胞对TNF-α 和IL-1β的炎症反应。3
Sirtinol可在 体内抑制酵母Sir2p转录沉默活性， 体外抑制酵母Sir2p和人SIRT2脱乙酰酶活性。
特點和優勢
这种化合物是基因调控研究的特色产品。点击此处发现更多特色基因调控产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
其他客户在看
Angela Orecchia et al.
PloS one, 6(9), e24307-e24307 (2011-09-21)
Histone deacetylases (HDAC) are key enzymes in the epigenetic control of gene expression. Recently, inhibitors of class I and class II HDAC have been successfully employed for the treatment of different inflammatory diseases such as rheumatoid arthritis, colitis, airway inflammation
H Mutoh et al.
The American journal of physiology, 261(1 Pt 1), G65-G70 (1991-07-01)
We examined the role of reduced glutathione as a defense mechanism against acid-induced gastric mucosal cell damage in vitro. Cellular stores of reduced glutathione were depleted by reaction with diethyl maleate (DEM) or 1-chloro-2,4-dinitrobenzene (CDNB) and increased by reaction with
Dong Ryeol Ryu et al.
Aging cell, 18(2), e12904-e12904 (2019-01-08)
Although it is known that the expression and activity of sirtuin 1 (Sirt1) decrease in the aged kidney, the role of interaction between Sirt1 and hypoxia-inducible factor (HIF)-1α is largely unknown. In this study, we investigated whether HIF-1α could be
Wenhao Zheng et al.
International immunopharmacology, 45, 135-147 (2017-02-19)
Osteoarthritis (OA) is a degenerative joint disease characterized by cartilage degradation and inflammation. Fisetin, a polyphenol extracted from fruits and vegetables, has been reported to have anti-inflammatory effects. Our study aimed to investigate the effect of fisetin on OA both
Na-Young Song et al.
Biochemical pharmacology, 153, 282-291 (2018-02-11)
Leptin, a representative adipokine secreted from the white adipose tissue, is considered as a potential linker between obesity and cancer. SIRT1 is an NAD+-dependent histone/protein deacetylase speculated to function as an oncogene. In the present study, we found that leptin
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门