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Merck
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主要文件

SML1045

Sigma-Aldrich

Thiazovivin

≥98% (HPLC), powder, Rho Kinase inhibitor

别名:

N-苄基-2-（嘧啶-4-基氨基）噻唑-4-甲酰胺

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About This Item

经验公式（希尔记法）:
C15H13N5OS
CAS号:
1226056-71-8
分子量:
311.36
分類程式碼代碼:
12352200
NACRES:
NA.77

产品名称

Thiazovivin, ≥98% (HPLC)

品質等級

100

化驗

≥98% (HPLC)

形狀

powder

顏色

, white to beige to brown

溶解度

DMSO: 20 mg/mL, clear

儲存溫度

−20°C

SMILES 字串

[s]1c(nc(c1)C(=O)NCc3ccccc3)Nc2ncncc2

InChI

1S/C15H13N5OS/c21-14(17-8-11-4-2-1-3-5-11)12-9-22-15(19-12)20-13-6-7-16-10-18-13/h1-7,9-10H,8H2,(H,17,21)(H,16,18,19,20)

InChI 密鑰

DOBKQCZBPPCLEG-UHFFFAOYSA-N

應用

Thiazovivin 已被用于从人尿液细胞生成诱导多能干细胞 (iPSC) 和诱导神经干细胞 (iNSC)。也用于研究促纤维化抑制对心脏重编程的影响。

生化／生理作用

Thiazovivin 是一种 Rho 激酶 (ROCK) 抑制剂。
Thiazovivin 是一种 Rho 激酶 (ROCK) 抑制剂，与 ALK5 抑制剂 SB-431542 (S4317) 和 MEK 抑制剂 PD-0325901 (PZ0162) 联合使用时，促进成纤维细胞向干细胞转化的效率比经典方法高 200 倍。Thiazovivin 可稳定细胞表面的上皮细胞钙粘蛋白，这是培养中人类胚胎干细胞生存所必需的。当人类胚胎干细胞从集落中剪出时，这种关键蛋白被破坏，然后在细胞内内化。细胞表面没有上皮细胞钙粘蛋白，细胞与其环境之间的细胞信号被破坏，细胞很快死亡。
Thiazovivin 是一种 Rho 相关的含卷曲螺旋的蛋白激酶 (ROCK) 抑制剂。体外研究证明，Thiazovivin 可有效刺激更好的形态、离子转运蛋白和细胞粘附相关蛋白的表达。

其他說明

2024年CiteAb奖，授予在帕金森研究方面取得成功的供应商

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000367112
0000338995
0000338994
0000338995
0000338994

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The ROCK inhibitor, thiazovivin, inhibits human corneal endothelial-to-mesenchymal transition/epithelial-to-mesenchymal transition and increases ionic transporter expression.
Wu Q, et al.
International Journal of Molecular Medicine, 40(4), 1009-1018 (2017)
Generation of Urine Cell-Derived Non-integrative Human iPSCs and iNSCs: A Step-by-Step Optimized Protocol.
Cheng L, et al.
Frontiers in Molecular Neuroscience, 10, 348-348 (2017)
Daniel A Armendariz et al.
eLife, 12 (2023-04-25)
Enhancers orchestrate gene expression programs that drive multicellular development and lineage commitment. Thus, genetic variants at enhancers are thought to contribute to developmental diseases by altering cell fate commitment. However, while many variant-containing enhancers have been identified, studies to endogenously
Yonatan R Lewis-Israeli et al.
Journal of visualized experiments : JoVE, (175) (2021-10-05)
The ability to study human cardiac development in health and disease is highly limited by the capacity to model the complexity of the human heart in vitro. Developing more efficient organ-like platforms that can model complex in vivo phenotypes, such
Kelli Johnson et al.
American journal of physiology. Cell physiology, 319(2), C321-C330 (2020-06-20)
Acetylcholine induces robust electrogenic anion secretion in mammalian intestine and it has long been hypothesized that it mediates the epithelial response through the M3 and, to a lesser extent, the M1 muscarinic receptors in the mouse. However, nicotinic receptors have
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