推荐产品
产品名称
嘌吗啡胺, ≥98% (HPLC)
质量水平
方案
≥98% (HPLC)
表单
powder
颜色
white to beige
溶解性
DMSO: 5 mg/mL, clear (warmed)
储存温度
−20°C
SMILES字符串
N7(CCOCC7)c1ccc(cc1)Nc2nc(nc5[n](cnc52)C6CCCCC6)Oc3c4c(ccc3)cccc4
InChI
1S/C31H32N6O2/c1-2-9-25(10-3-1)37-21-32-28-29(33-23-13-15-24(16-14-23)36-17-19-38-20-18-36)34-31(35-30(28)37)39-27-12-6-8-22-7-4-5-11-26(22)27/h4-8,11-16,21,25H,1-3,9-10,17-20H2,(H,33,34,35)
InChI key
FYBHCRQFSFYWPY-UHFFFAOYSA-N
应用
Purmorphamine已被用于研究Tupfel长鳍株斑马鱼中Hedgehog信号通路上调的影响。[1]
生化/生理作用
Purmorphamine可直接结合Smoothened（Smo）受体，激活Hedgehog（Hh）信号通路。
Purmorphamine可直接结合Smoothened（Smo）受体，激活Hedgehog（Hh）信号通路。多项研究已经显示，Purmorphamine可诱导成骨细胞的分化、从人胚胎干细胞中产生心肌细胞、增加人纹状体神经干细胞系的神经元分化、以及将人脐带间充质干细胞（hUCMSC）分化成运动神经元。
警示用语：
Warning
危险声明
危险分类
Muta. 2
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
其他客户在看
Shabana Amanda Ali et al.
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With no effective therapies to attenuate cartilage degeneration in osteoarthritis (OA), the result is pain and disability. Activation of hedgehog (HH) signaling causes changes related to the progression of OA, with higher levels of Gli-mediated transcriptional activation associated with increased
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Cofer Z C, et al.
PLoS ONE, 11(3), e0151521-e0151521 (2016)
Tobias Bohnenpoll et al.
PLoS genetics, 13(8), e1006951-e1006951 (2017-08-11)
The differentiated cell types of the epithelial and mesenchymal tissue compartments of the mature ureter of the mouse arise in a precise temporal and spatial sequence from uncommitted precursor cells of the distal ureteric bud epithelium and its surrounding mesenchyme.
Kimberly F Atkinson et al.
Cells, 8(7) (2019-07-25)
Biosensors on the membrane of the vascular endothelium are responsible for sensing mechanical and chemical signals in the blood. Transduction of these stimuli into intracellular signaling cascades regulate cellular processes including ion transport, gene expression, cell proliferation, and/or cell death.
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