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Merck
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主要文件

SML0832

Sigma-Aldrich

TLR4-IN-C34

≥98% (HPLC)

别名:

2-乙酰氨基吡喃糖苷, C34, 异丙基 2-（乙酰氨基）-2-脱氧 α-D-吡喃葡萄糖苷 3,4,6-三乙酸酯

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About This Item

经验公式（希尔记法）:
C17H27NO9
CAS号:
40592-88-9
分子量:
389.40
UNSPSC代码:
51111800
NACRES:
NA.77

质量水平

100

方案

≥98% (HPLC)

表单

powder

储存条件

desiccated

颜色

white to beige

溶解性

H2O: 1 mg/mL, clear (warmed)

储存温度

−20°C

SMILES字符串

N([C@H]1[C@H](O[C@@H]([C@H]([C@@H]1OC(=O)C)OC(=O)C)COC(=O)C)OC(C)C)C(=O)C

InChI

1S/C17H27NO9/c1-8(2)24-17-14(18-9(3)19)16(26-12(6)22)15(25-11(5)21)13(27-17)7-23-10(4)20/h8,13-17H,7H2,1-6H3,(H,18,19)/t13-,14-,15-,16-,17+/m1/s1

InChI key

KMIQMFHPUJUDMC-HHARLNAUSA-N

一般描述

TLR4-IN-C34 是体外和体内 toll 样受体 4（TLR4）的抑制剂。

应用

TLR4-IN-C34 已作为一种抑制剂用在喂食高脂饮食的小鼠中，以在体内验证上述体外途径（硬脂酸/LDH-α/细胞因子）。

生化/生理作用

TLR4-IN-C34 是 toll 样受体 4（TLR4）的有效和特异性抑制剂，其在体内和体外抑制 TLR4 信号转导。TLR4-IN-C34，也称为 C34，是一种氨基单糖，通过与 TLR4 的共同受体-髓样分化蛋白-2 (MD-2)的疏水口袋对接来抑制 TLR4 信号。研究表明，C34 可降低实验性坏死性小肠结肠炎（NEC）的严重程度。
TLR4-IN-C34 是 toll 样受体 4（TLR4）的有效特异性抑制剂。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000160022
0000167204
0000167203
024M4760V

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Elikanah Olusayo Adegoke et al.
Journal of applied toxicology : JAT, 39(6), 832-843 (2019-01-24)
This study investigated the pharmacological inhibition of the toll-like receptor 4 (TLR4) genes as a measure to attenuate microcystin-LR (MC-LR) reproductive toxicity. Bovine Sertoli cells were pretreated with TLR4-IN-C34 (C34) for 1 hour. Thereafter the pretreated and non-pretreated Sertoli cells were
Elikanah Olusayo Adegoke et al.
Journal of applied toxicology : JAT, 39(6), 832-843 (2019-01-24)
This study investigated the pharmacological inhibition of the toll-like receptor 4 (TLR4) genes as a measure to attenuate microcystin-LR (MC-LR) reproductive toxicity. Bovine Sertoli cells were pretreated with TLR4-IN-C34 (C34) for 1 hour. Thereafter the pretreated and non-pretreated Sertoli cells were
Stearic acid induces proinflammatory cytokine production partly through activation of lactate-HIF1α pathway in chondrocytes.
Miao H, et al.
Scientific Reports, 5, 13092-13092 (2015)
Peter Wipf et al.
Tetrahedron letters, 56(23), 3097-3100 (2015-08-04)
The low-molecular weight isopropyl 2-acetamido-α-glucoside 16 (C34) inhibits toll-like receptor 4 (TLR4) in enterocytes and macrophages in vitro, and reduces systemic inflammation in mouse models of endotoxemia and necrotizing enterocolitis. We used a copper(II)-mediated solvolysis of anomeric oxazolines and an
Eric Wildon Kostuk et al.
Journal of neuroinflammation, 15(1), 139-139 (2018-05-13)
Parkinson's disease (PD) is characterized by selective degeneration of dopaminergic (DA) neurons of the substantia nigra pars compacta (SN) while neighboring ventral tegmental area (VTA) DA neurons are relatively spared. Mechanisms underlying the selective protection of the VTA and susceptibility
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