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Merck
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文件

SML0203

Sigma-Aldrich

iCRT14

≥98% (HPLC)

别名:

5-[[2,5-二甲基-1-（3-吡啶基）-1H-吡咯-3-基]亚甲基]-3-苯基-2,4-噻唑烷二酮

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About This Item

经验公式（希尔记法）:
C21H17N3O2S
CAS号:
677331-12-3
分子量:
375.44
MDL號碼:
MFCD04366833
分類程式碼代碼:
12352200
PubChem物質ID:
329825227
NACRES:
NA.77

品質等級

100

化驗

≥98% (HPLC)

形狀

powder

顏色

yellow to orange

溶解度

DMSO: ≥10 mg/mL

儲存溫度

2-8°C

SMILES 字串

Cc1cc(\C=C2/SC(=O)N(c3ccccc3)C2=O)c(C)n1-c4cccnc4

InChI

1S/C21H17N3O2S/c1-14-11-16(15(2)23(14)18-9-6-10-22-13-18)12-19-20(25)24(21(26)27-19)17-7-4-3-5-8-17/h3-13H,1-2H3/b19-12-

InChI 密鑰

NCSHZXNGQYSKLR-UNOMPAQXSA-N

應用

iCRT14可用于Wnt /β-连环蛋白介导的细胞信号转导研究。

生化／生理作用

iCRT14属于噻唑烷二酮类β-连环蛋白反应性转录抑制剂。它可降低散乱蛋白的水平并调节T细胞因子（TCF）与DNA的结合。 它会导致结肠癌细胞中细胞增殖和肿瘤生长减少的持续减弱。
iCRT14是一种Wnt / β-连环蛋白途径抑制剂。它是连环蛋白应答转录（CRT）报告基因的有效抑制剂，以及内源基因靶标。iCRT14还可以剂量依赖性方式破坏β-连环蛋白-TCF4的相互作用，并在结肠肿瘤细胞系中引起G0/G1 的停滞。

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

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Xin Wang et al.
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In colorectal cancer, Wnt/β-catenin signaling is often aberrantly activated and associated with a T-cell-excluded phenotype which is a major obstacle for many immunotherapies. However, the effects of Wnt/β-catenin inhibition on tumor immunity and immunotherapy remain to be elucidated. In syngeneic
Winning WNT: race to Wnt signaling inhibitors.
Kazuhide Watanabe et al.
Proceedings of the National Academy of Sciences of the United States of America, 108(15), 5929-5930 (2011-04-01)
The S-G2 phase enriched beta-catenin/TCF complex ensures cell survival and cell cycle progression
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