所有图片(1)
About This Item
经验公式（希尔记法）:
C17H11BrN2O2
CAS号:
分子量:
355.19
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77
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品質等級
化驗
≥98% (HPLC)
形狀
powder
顏色
white to beige
溶解度
DMSO: 15 mg/mL (clear solution)
儲存溫度
2-8°C
SMILES 字串
Brc1cccc(c1)C2=NCC(=O)Nc3c2oc4ccccc34
InChI
1S/C17H11BrN2O2/c18-11-5-3-4-10(8-11)15-17-16(20-14(21)9-19-15)12-6-1-2-7-13(12)22-17/h1-8H,9H2,(H,20,21)
InChI 密鑰
NKYMVQPXXTZHSF-UHFFFAOYSA-N
生化／生理作用
5-BDBD 是 P2X4 的特异性抑制剂。该化合物抑制 CHO 细胞中的 P2X4 电流，IC50 为 500nM。
在天然组织中，5-BDBD被认为是分析P2X受体（P2XRs）亚型P2X4R作用的有益拮抗剂。
特點和優勢
该化合物的相关信息整理于受体分类和信号转导手册的 P2受体：P2X离子通道家族 页面。欲浏览其他手册页面，请 点击这里。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
其他客户在看
Ting Long et al.
Journal of neuroinflammation, 15(1), 245-245 (2018-09-01)
The mechanism underlying migraine chronification remains unclear. Central sensitization may account for this progression. The microglia P2X4 receptor (P2X4R) plays a pivotal role in the central sensitization of inflammatory and neuropathic pain, but there is no information about P2X4R in
Hyuck Joon Kwon et al.
Scientific reports, 6, 39302-39302 (2016-12-23)
Electrical stimulation (ES) is known to guide the development and regeneration of many tissues. However, although preclinical and clinical studies have demonstrated superior effects of ES on cartilage repair, the effects of ES on chondrogenesis remain elusive. Since mesenchyme stem
Bing Hu et al.
Iranian journal of basic medical sciences, 21(4), 364-369 (2018-05-26)
P2X4R is expressed in immunocyte and lung tissues. It has been a focus in inflammatory responses recently. This study investigated whether blockage of P2X4R attenuates allergic inflammation by modulating T cell response in ovalbumin-sensitized mice. Ovalbumin was used to sensitize
Yun-Ming Tu et al.
Food & function, 8(12), 4336-4346 (2017-09-25)
Circulating levels of free fatty acids (FFAs) are often found to be increased in patients with type 2 diabetes mellitus (T2DM) and metabolic syndrome (MS). High plasma FFA levels may give rise to maladaptive macrophage activation and promote inflammatory responses
Andreas Zech et al.
Oncotarget, 7(49), 80288-80297 (2016-11-20)
Compelling evidences point out a crucial role for extracellular nucleotides such as adenosine triphosphate (ATP) during inflammatory conditions. Once released into the extracellular space, ATP modulates migration, maturation and function of various inflammatory cells via activating of purinergic receptors of
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