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M6517

Sigma-Aldrich

Α, β-亚甲基腺苷 5′-三磷酸盐 锂盐

≥93% (HPLC), solid

别名:

AMP-CPP

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About This Item

经验公式（希尔记法）:
C11H18N5O12P3 · xLi+
CAS号:
104809-20-3
分子量:
505.21 (free acid basis)
MDL號碼:
MFCD00148925
分類程式碼代碼:
41106305
eCl@ss:
32160414
PubChem物質ID:
24277720
NACRES:
NA.77

品質等級

200

化驗

≥93% (HPLC)

形狀

solid

顏色

white

溶解度

H2O: 100 mg/mL

儲存溫度

−20°C

SMILES 字串

[Li+].Nc1ncnc2n(cnc12)[C@@H]3O[C@H](COP(O)(=O)CP(O)(=O)OP(O)([O-])=O)[C@@H](O)[C@H]3O

InChI

1S/C11H18N5O12P3.Li/c12-9-6-10(14-2-13-9)16(3-15-6)11-8(18)7(17)5(27-11)1-26-29(19,20)4-30(21,22)28-31(23,24)25;/h2-3,5,7-8,11,17-18H,1,4H2,(H,19,20)(H,21,22)(H2,12,13,14)(H2,23,24,25);/q;+1/p-1/t5-,7-,8-,11-;/m1./s1

InChI 密鑰

NVHVREPTGDOYIC-YCSZXMBFSA-M

基因資訊

human ... P2RX1(5023)

相关类别

應用

α,β-亚甲基腺苷 5'-三磷酸锂盐已：
  • 用作P2-嘌呤受体激动剂 (P2X)，以分析其对尾核星形胶质细胞膜电导的影响；
  • 用作P2X受体激动剂， 增加卫星细胞神经元中的钙电流，以
  • 确定嘌呤能激动剂对大鼠P2Y受体的功能敏感性，并确定其对发展外窦细胞的影响

生化／生理作用

P2 嘌呤受体激动剂，在 P2X 亚型比 ATP 更有效。

特點和優勢

该化合物的相关信息整理于受体分类和信号转导手册的 P2受体：P2X 离子通道家族和P2 受体：《受体分类和信号转导》手册的 P2Y G 蛋白家族页面有该化合物的介绍。想要浏览手册的其他页面， 请单击此处。

外觀

吸湿性固体

象形圖

Exclamation mark
GHS07

訊號詞

Warning

危險聲明

H315,H319,H335

危險分類

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

標靶器官

Respiratory system

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves

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Catherine A Regni et al.
The EMBO journal, 28(13), 1953-1964 (2009-06-06)
The 39-kDa Escherichia coli enzyme MccB catalyses a remarkable posttranslational modification of the MccA heptapeptide during the biosynthesis of microcin C7 (MccC7), a 'Trojan horse' antibiotic. The approximately 260-residue C-terminal region of MccB is homologous to ubiquitin-like protein (UBL) activating
Tanumoy Mondol et al.
Nucleic acids research, 47(4), 1977-1986 (2019-01-04)
DNA polymerase delta (Pol δ) is responsible for the elongation and maturation of Okazaki fragments in eukaryotic cells. Proliferating cell nuclear antigen (PCNA) recruits Pol δ to the DNA and serves as a processivity factor. Here, we show that PCNA
G Burnstock et al.
General pharmacology, 16(5), 433-440 (1985-01-01)
It is suggested that the P2-purinoceptor may be separated into two subtypes largely on the basis of the rank order of agonist potency of structural analogues of ATP and also on the activity of antagonists at the P2-purinoceptor: Subtype 1
D J Trezise et al.
British journal of pharmacology, 112(1), 282-288 (1994-05-01)
1. We have previously found that the P2x-purinoceptor agonist, alpha, beta-methylene adenosine 5'-triphosphate (alpha, beta-methylene ATP), depolarizes the rat cervical vagus nerve, measured with a 'grease-gap' extracellular recording technique. This effect was attenuated by the P2 purinoceptor antagonist, suramin. In
X Bo et al.
British journal of urology, 76(3), 297-302 (1995-09-01)
To characterize [3H] alpha, beta-methylene adenosine 5'-triphosphate ([3H] alpha, beta-MeATP, a radioligand for P2x-purinoceptors) binding sites in the washed homogenates and membrane preparations of human urinary bladder and, using autoradiography, to localize [3H] alpha, beta-MeATP binding sites in human bladder.
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