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生物源
mouse
抗體表格
purified from hybridoma cell culture
抗體產品種類
primary antibodies
無性繁殖
PD-65, monoclonal
形狀
buffered aqueous solution
分子量
~42 kDa
物種活性
bovine, rat, human, mouse
包裝
antibody small pack of 25 μL
濃度
1 mg/mL
技術
immunoblotting: 0.25-0.5 μg/mL using using human HEK-293T cells.
immunofluorescence: 1-2 μg/mL using human HEK-293T cells.
同型
IgG2a
UniProt登錄號
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... NPHS2(7827)
一般說明
足细胞是覆盖肾脏肾小球外部的高度专用化内脏上皮细胞。相邻足细胞的足突会经常发生相互交叉，留下了由狭缝薄膜桥连的滤过隙。这是一种细胞外粘附样连接，可作为大分子的屏障并在肾小球滤过过程中起关键作用。Podocin（NPHS2蛋白）是一组与狭缝膜有关的蛋白质中的重要成员。Podocin属于脂筏相关蛋白的band-7-stomatin家族。它是一种带有细胞内N和C末端的发卡样整合膜蛋白。Podocin位于狭缝膜的插入位点，被认为是维持或调节狭缝膜结构完整性所需的一种支架蛋白。它在那里会与肾病蛋白（NPHS1蛋白）相互作用，而肾病蛋白对肾脏滤过屏障和衔接蛋白CD2-AP的发育和功能至关重要。Podocin被锚定在质膜外小叶上富含糖鞘脂和胆固醇的脂筏中，并可用肌动蛋白细胞骨架进行部分定位。体外研究表明它参与了HEK细胞中通过AP-1的肾病蛋白信号转导促进。除了存在于肾脏中外，它还被报道存在于大鼠神经组织以及可能的血管平滑肌中。
免疫原
与KLH偶联的人Podocin的合成肽
應用
该抗体可用于各种免疫化学技术，包括免疫印迹（~42kDa）和免疫荧光。通过免疫印迹对Podocin条带的检测可被免疫原特异性的抑制。
外觀
本品为溶液形式，溶于0.01M磷酸盐缓冲盐水，pH 7.4，含有15 mM叠氮化钠作为防腐剂
其他說明
本产品仅供研发使用，不得用于药物、家庭或其他用途。
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
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