跳转至内容
Merck
所有图片(1)

主要文件

查看所有文档

S4568

Sigma-Aldrich

SCH 58261

≥98% (HPLC), solid

别名:

7-(2-苯乙基)-5-氨基-2-(2-呋喃基)-吡唑并-[4,3-e]-1,2,4-三唑并[1,5-c]嘧啶

登录查看公司和协议定价
所有图片(1)

About This Item

经验公式（希尔记法）:
C18H15N7O
CAS号:
160098-96-4
分子量:
345.36
MDL號碼:
MFCD00933778
分類程式碼代碼:
12352200
PubChem物質ID:
329824547
NACRES:
NA.77
价格与库存信息目前不能提供

品質等級

100

化驗

≥98% (HPLC)

形狀

solid

顏色

off-white

溶解度

DMSO: soluble >10 mg/mL
H2O: insoluble

SMILES 字串

Nc1nc2n(CCc3ccccc3)ncc2c4nc(nn14)-c5ccco5

InChI

1S/C18H15N7O/c19-18-22-16-13(11-20-24(16)9-8-12-5-2-1-3-6-12)17-21-15(23-25(17)18)14-7-4-10-26-14/h1-7,10-11H,8-9H2,(H2,19,22)

InChI 密鑰

UTLPKQYUXOEJIL-UHFFFAOYSA-N

應用

SCH 58261被用于阻断A2α腺苷酸受体，以研究神经元中前列腺酸性磷酸酶的信号传导。4

生化／生理作用

A2A 腺苷受体拮抗剂。
SCH 58261能够降低TNF-α、Fas-L、Bax表达以及JNK-MAPK通路的活化水平。它具有神经保护作用，因为它可以减少神经元的脱髓鞘。[1] SCH 58261能够提高多巴胺的分泌浓度并引发运动致敏，这是一个有吸引力的潜在帕金森氏病治疗方法。[2]

特點和優勢

《受体分类和信号转导》手册的 腺苷受体页有该化合物的介绍。想要浏览手册的其他页面， 请单击此处。

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000187942
0000187943
037M4736V
026M4720V
025M4779V

没有发现合适的版本？

如果您需要特殊版本，可通过批号或批次号查找具体证书。

搜索COA

已有该产品？

在文件库中查找您最近购买产品的文档。

访问文档库

Mushtaq A Ansari et al.
Molecular and cellular neurosciences, 82, 76-87 (2017-05-04)
Autism spectrum disorder (ASD) is neurodevelopmental disorders characterized by stereotypical repetitive behavior, impaired social interaction, and deficits in communication. The BTBR T
Cristiani F Bortolatto et al.
Metabolic brain disease, 32(6), 1919-1927 (2017-08-11)
The aim of the present study was to investigate the effects of SCH58261, a selective adenosine A
Sheikh F Ahmad et al.
Journal of neuroimmunology, 311, 59-67 (2017-08-16)
Autism is a complex heterogeneous neurodevelopmental disorder; previous studies have identified altered immune responses among individuals diagnosed with autism. An imbalance in the production of pro- and anti-inflammatory cytokines and transcription factors plays a role in neurodevelopmental behavioral and autism
Aderbal S Aguiar et al.
Scientific reports, 10(1), 13414-13414 (2020-08-10)
Caffeine is one of the most used ergogenic aid for physical exercise and sports. However, its mechanism of action is still controversial. The adenosinergic hypothesis is promising due to the pharmacology of caffeine, a nonselective antagonist of adenosine A1 and
Chih W Hsu et al.
Journal of biomedical science, 17, 4-4 (2010-01-16)
Caffeine, a nonselective adenosine A1 and A(2A) receptor antagonist, is the most widely used psychoactive substance in the world. Evidence demonstrates that caffeine and selective adenosine A(2A) antagonists interact with the neuronal systems involved in drug reinforcement, locomotor sensitization, and
查看所有相关文献

Questions

Reviews

No rating value

Active Filters

我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系技术服务部门