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Merck

RAB1138

Sigma-Aldrich

大鼠BDNF ELISA试剂盒

for cell culture supernatants, plasma, and serum samples

别名:

BDNF, Brain-derived neurotrophic factor

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About This Item

UNSPSC代码:
41116158
NACRES:
NA.32

种属反应性

human, rat

包装

kit of 96 wells (12 strips x 8 wells)

技术

ELISA: suitable

输入

sample type plasma
sample type cell culture supernatant(s)
sample type serum sample(s)

assay range

inter-assay cv: <12%
intra-assay cv: <10%
sensitivity: 12 pg/ml

检测方法

colorimetric

运输

wet ice

储存温度

−20°C

基因信息

rat ... Bdnf(24225)

一般描述

脑源性神经营养因子(BDNF)基因定位于人类染色体11p14.1上。该基因编码前体蛋白proBDNF。成熟的BDNF(mBDNF)是通过proBDNF的翻译后切割合成的。
该ELISA抗体对可检测大鼠和人BDNF。其他物种尚未测定。

应用

仅供研究使用。不可用于诊断操作。
详细内容请参阅附件实验方案

生化/生理作用

脑源性神经营养因子(BDNF)参与人类的海马功能和言语情节记忆。BDNF在血管功能中也起着至关重要的作用,并通过特异性受体原肌球蛋白相关激酶B(TrkB)参与血管生成。它参与了阿尔茨海默′病的发病机制。

其他说明

本产品提供了样品检验报告。请在批号对应的文本框中输入样品一词。

象形图

Corrosion

警示用语:

Warning

危险声明

预防措施声明

危险分类

Met. Corr. 1

储存分类代码

8A - Combustible corrosive hazardous materials

闪点(°F)

Not applicable

闪点(°C)

Not applicable


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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其他客户在看

Jie Kang et al.
Brain sciences, 11(1) (2020-12-31)
(1) Background: Depression is one of the overwhelming public health problems. Alleviating hippocampus injury may prevent depression development. Herein, we established the chronic unpredictable mild stress (CUMS) model and aimed to investigate whether aerobic exercise (AE) could alleviate CUMS induced
Peripheral vascular reactivity and serum BDNF responses to aerobic training are impaired by the BDNF Val66Met polymorphism.
Lemos JR Jr, et al.
Physiological Genomics, 48(2), 116-123 (2015)
The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function.
Egan MF, et al.
Cell, 112(2), 257-269 (2003)
Irina Naletova et al.
International journal of molecular sciences, 22(24) (2021-12-25)
l-carnosine (β-alanyl-l-histidine) (Car hereafter) is a natural dipeptide widely distributed in mammalian tissues and reaching high concentrations (0.7-2.0 mM) in the brain. The molecular features of the dipeptide underlie the antioxidant, anti-aggregating and metal chelating ability showed in a large
11p14. 1 microdeletions associated with ADHD, autism, developmental delay, and obesity.
Shinawi M, et al.
American Journal of Medical Genetics. Part A, 155(6), 1272-1280 (2011)

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