![2-脱氧-2-[（7-硝基-2,1,3-苯并恶二唑-4-基）氨基]-D-葡萄糖 ≥97% (HPLC)](/deepweb/assets/sigmaaldrich/product/structures/104/527/40bd5a41-ebc4-484e-a10e-891fecfaea79/640/40bd5a41-ebc4-484e-a10e-891fecfaea79.png)
There is no information on the solution stability of aqueous solutions of this product. So it would be best to prepare fresh solutions as needed.
价格与库存信息目前不能提供
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生物源
synthetic (organic)
品質等級
化驗
≥99% (GC)
形狀
crystalline
技術
gas chromatography (GC): suitable
顏色
white
mp
146-147 °C (lit.)
溶解度
H2O: soluble 330 mg/mL, clear, colorless
儲存溫度
2-8°C
SMILES 字串
OC[C@@H](O)[C@@H](O)[C@H](O)CC=O
InChI
1S/C6H12O5/c7-2-1-4(9)6(11)5(10)3-8/h2,4-6,8-11H,1,3H2/t4-,5-,6+/m1/s1
InChI 密鑰
VRYALKFFQXWPIH-PBXRRBTRSA-N
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應用
2-Deoxy-D-glucose (2-DG) is used in glucoprivic feeding research to invoke and study the processes of counter-regulatory response (CRR). 2-Deoxy-D-glucose is used in the development of anti-cancer strategies that involve radio- and chemosensitization and oxidative stress.
生化／生理作用
2-脱氧-D-葡萄糖（2-脱氧葡萄糖）是一种葡萄糖类似物，可通过作用于己糖激酶这一糖酵解限速步骤来抑制糖酵解。 它会被己糖激酶磷酸化为不能被磷酸葡萄糖异构酶进一步代谢的2-DG-P。 这将导致2-DG-P在细胞中的集聚以及细胞ATP的缺失。在体外，2-脱氧葡萄糖已显示出可诱导自噬、提高ROS的产生并激活AMPK。
準備報告
A further purification of the Grade II material by recrystallization.
其他說明
To gain a comprehensive understanding of our extensive range of Monosaccharides for your research, we encourage you to visit our Carbohydrates Category page.
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
其他客户在看
Rosemarie Ungricht et al.
The Journal of cell biology, 209(5), 687-703 (2015-06-10)
Newly synthesized membrane proteins are constantly sorted from the endoplasmic reticulum (ER) to various membranous compartments. How proteins specifically enrich at the inner nuclear membrane (INM) is not well understood. We have established a visual in vitro assay to measure
Alfredo J Ibáñez et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(22), 8790-8794 (2013-05-15)
Single-cell level measurements are necessary to characterize the intrinsic biological variability in a population of cells. In this study, we demonstrate that, with the microarrays for mass spectrometry platform, we are able to observe this variability. We monitor environmentally (2-deoxy-D-glucose)
Paramita Chakraborty et al.
Cell reports, 28(7), 1879-1893 (2019-08-15)
Sphingosine 1-phosphate (S1P), a bioactive lysophospholipid generated by sphingosine kinase 1 (SphK1), regulates lymphocyte egress into circulation via S1P receptor 1 (S1PR1) signaling, and it controls the differentiation of regulatory T cells (Tregs) and T helper-17 cells. However, the mechanisms by
Melissa A Burmeister et al.
American journal of physiology. Endocrinology and metabolism, 304(7), E677-E685 (2013-01-24)
Glucagon-like peptide-1 (GLP-1) suppresses food intake via activation of a central (i.e., brain) GLP-1 receptor (GLP-1R). Central AMP-activated protein kinase (AMPK) is a nutrient-sensitive regulator of food intake that is inhibited by anorectic signals. The anorectic effect elicited by hindbrain
Yi-Deun Jung et al.
Cancers, 11(3) (2019-03-01)
Excess lactate production due to enhanced aerobic glycolysis is characteristic of malignant cancers, which is also intimately associated with poor cancer prognoses. Although tumor-associated lactate contributes to all major steps in carcinogenesis, its action mechanism remains obscure. To understand the
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We presents an article on Autophagy in Cancer Promotes Therapeutic Resistance
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CAN THIS PRODUCT BE PREPARED IN WATER, AND FROZEN IN ALIQUOTS FOR LONG-TERM STORAGE?
1 answer-
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Can this product be prepared in DMSO, and frozen in aliquots for long-term storage?
1 answer-
The chemical can be solubilized in DMSO (up to 190 mg/ml). Per literature reference, 1 M stock solutions of 2-deoxyglucose can be stored at -20 °C. Brandizzi, F., et al., Membrane Protein Transport between the Endoplasmic Reticulum and the Golgi in Tobacco Leaves Is Energy Dependent but Cytoskeleton Independent: Evidence from Selective Photobleaching. The Plant Cell, 14, 1293-1309 (2002). (Direct link to paper: http://www.plantcell.org/content/14/6/1293.full)
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What is the shelf life of 2-Deoxy-D-glucose, Product D6134?
1 answer-
There is no recommended retest date given to released lots for this product. The product is guaranteed to be of good quality for one year from the time you receive it; this guarantee applies only to unopened bottles which have been stored at room temperature.
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How can I dissolve 2-Deoxy-D-glucose, Product D6134?
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The product is soluble in water at 330 mg/mL. It may also be soluble in DMSO.
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What are the differences between products D6134 and D8375 which are both 2-deoxy-D-glucose?
1 answer-
Product D6134 is a further purification by crystallization of D8375.
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Can solutions of 2-Deoxy-D-glucose, Product D6134, be stored?
1 answer-
Sigma-Aldrich has no information on the solution stability of this product. If information can't be found in the literature, it is best to prepare fresh solutions.
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What is the Department of Transportation shipping information for this product?
1 answer-
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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