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生物源
rabbit
品質等級
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
分子量
antigen ~24 kDa
物種活性
human, mouse, rat
濃度
~1 mg/mL
技術
indirect immunofluorescence: 5-10 μg/mL using rat NRK and mouse NIH-3T3 cells.
western blot: 2.5-5 μg/mL using whole extract of human A431 cells
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... RAB5A(5868)
mouse ... Rab5a(271457)
rat ... Rab5a(64633)
一般說明
Ras related protein consists of three isoforms such as Rab5a, Rab5b and Rab5c. Rab5a is encoded by the gene mapped to human chromosome 3p24.3. This gene codes for 23.66 kDa Rab5a protein.
免疫原
synthetic peptide corresponding to amino acid residues 176-188 of human Rab5 with C-terminal added cysteine, conjugated to KLH.
應用
Anti-Rab5 antibody produced in rabbit has been used in western blotting and immunocytochemistry.
生化／生理作用
Rab proteins are members of small GTPases control the exocytosis and endocytosis and regulate vesicular transport. Rab5 regulates endocytic pathway in mammalian cells and an activator of autophagy. It mediates macroautophagy of cells expressing aggregates of mutant Huntingtin protein.
Rab5a is essential for epidermal growth factor (EGF)-mediated EGF receptor degradation. Overexpression of Rab5a is associated with the development of variety of cancers such as breast cancer, lung cancer, hepatocellular carcinoma (HCC) and ovarian cancer.
外觀
Solution in 0.01 M phosphate buffered saline, pH 7.4, and 15 mM sodium azide.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Site-specific monoubiquitination downregulates Rab5 by disrupting effector binding and guanine nucleotide conversion
Shin D, et al.
eLife, 6, e29154-e29154 (2017)
J Somsel Rodman et al.
Journal of cell science, 113 Pt 2, 183-192 (2000-01-14)
Endocytosis is characterized by vesicular transport along numerous pathways. Common steps in each pathway include membrane budding to form vesicles, transport to a particular destination, and ultimately docking and fusion with the target membrane. Specificity of vesicle targeting is rendered
Lysosomal network proteins as potential novel CSF biomarkers for Alzheimer?s disease
Armstrong A, et al.
Neuromolecular Medicine, 16(1), 150-160 (2014)
Rab5a promotes the migration and invasion of hepatocellular carcinoma by up-regulating Cdc42
Yang X, et al.
International Journal of Clinical and Experimental Pathology, 11(1), 224-231 (2018)
Microvesicle and tunneling nanotube mediated intercellular transfer of g-protein coupled receptors in cell cultures
Guescini M, et al.
Experimental Cell Research, 318(5), 603-613 (2012)
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