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产品名称
Platelet-Derived Growth Factor-AA 人, PDGF-AA, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture
生物源
human
品質等級
重組細胞
expressed in E. coli
化驗
≥98% (SDS-PAGE and HPLC)
形狀
lyophilized powder
效力
1.0-3.0 ng/mL ED50
品質
endotoxin tested
分子量
28.5 kDa (containing 250 amino acid residues)
包裝
pkg of 10 μg
pkg of 50 μg
儲存條件
avoid repeated freeze/thaw cycles
技術
cell culture | mammalian: suitable
雜質
<1 EU/μg
UniProt登錄號
儲存溫度
−20°C
基因資訊
human ... PDGFRA(5154)
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一般說明
Platelet-derived growth factor (PDGF) is composed two polypeptide subunits of A and B chain. PDGF is produced by a number of cells including smooth muscle cells, endothelial cells and macrophages.[1] The PDGF gene is highly conserved and is mapped to human chromosome 7p22.3.[2][3] PDGF is structurally and functionally related to vascular endothelial growth factors.[3]
生化／生理作用
Cell division and relocalization of pulmonary artery smooth muscle cells and fibroblasts is known to be triggered by platelet-derived growth factor (PDGF). Due to its proliferatory function, it is associated with fibroproliferative disorders such as atherosclerosis, pulmonary arterial hypertension and lung fibrosis. PDGF exists both in homo and heterodimeric forms and stimulates α and β-cell surface receptors.[1] Vascular endothelial growth factor expression is regulated by PDGF-AA autocrine signalling and is known to promote tumor angiogenesis in vivo.[4]
其他說明
Homodimer of the A chain of human PDGF.
外觀
Lyophilized from a sterile filtered buffered solution.
分析報告
The biological activity is measured by the dose-dependent stimulation of thymidine uptake by BALB/c 3T3 cells.
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 2
閃點（°F）
Not applicable
閃點（°C）
Not applicable
其他客户在看
Platelet-derived growth factor-AA is an essential and autocrine regulator of vascular endothelial growth factor expression in non?small cell lung carcinomas.
Shikada Y, et al.
Cancer Research, 65.16, 7241-7248 (2005)
Clinical Findings Associated with a De Novo Partial Trisomy 10p11. 22p15. 3 and Monosomy 7p22. 3 Detected by Chromosomal Microarray Analysis.
Kohannim O, et al.
Case Reports in Genetics, 2011 (2011)
Role of platelet-derived growth factors in physiology and medicine.
Andrae J, et al.
Genes & Development, 22.10, 1276-1312 (2008)
Luana Abballe et al.
Frontiers in pediatrics, 6, 315-315 (2018-11-18)
Numb is an intracellular protein with multiple functions. The two prevalent isoforms, Numb p66 and Numb p72, are regulators of differentiation and proliferation in neuronal development. Additionally, Numb functions as cell fate determinant of stem cells and cancer stem cells
Hélène Jamann et al.
Frontiers in immunology, 13, 850616-850616 (2022-04-29)
Multiple sclerosis (MS) is characterized by the loss of myelin and of myelin-producing oligodendrocytes (OLs) in the central nervous system (CNS). Pro-inflammatory CD4+ Th17 cells are considered pathogenic in MS and are harmful to OLs. We investigated the mechanisms driving
商品
Platelet-Derived Growth Factor is the principal mitogen found in mammalian serum and is released from platelets during clot formation.
血小板衍生生长因子是在哺乳动物血清中发现的主要有丝分裂原，在血栓形成过程中从血小板释放。
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