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Merck
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主要文件

M8631

Sigma-Aldrich

黑色素

Synthetic

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About This Item

CAS号:
8049-97-6
EC 号:
232-473-6
MDL编号:
MFCD00131581
UNSPSC代码:
12352204
NACRES:
NA.83
价格与库存信息目前不能提供

质量水平

100

表单

powder

储存温度

−20°C

SMILES字符串

[nH]1c2c3c(c4c5c([nH]c4)c([c]([c](c5c3c1)=O)=O)C)[c]([c](c2C)=O)=O

InChI

1S/C18H10N2O4/c1-5-13-9-7(3-19-13)12-10-8(11(9)17(23)15(5)21)4-20-14(10)6(2)16(22)18(12)24/h3-4,19-20H,1-2H3

InChI key

XUMBMVFBXHLACL-UHFFFAOYSA-N

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相关类别

一般描述

黑色素是存在于脊椎动物表面结构中的重要色素，[1]可导致皮肤变色。[2]它具有三种形式，如：真黑素(​eumelanin)，褐黑素(pheomelanin)，神经黑素(neuromelanin)。[2]黑色素具有阳离子螯合和氧化还原特性。它是强效的光吸收剂。黑色素起化学保护和光保护性颜料的作用。该基因的突变与眼白化病、白癜风、花斑病和瓦登伯格综合征有关。[1]

应用

黑色素已用于：
  • 分光光度法测定[3]
  • 研究其对逆转录聚合酶链式反应(RT-PCR)的抑制作用以及BSA（牛血清白蛋白）在克服抑制作用方面的作用[4]
  • 用作近红外组织光谱中皮肤层的吸收剂[5]
  • 拉曼光谱分析[6]

制备说明

通过使用过氧化氢对酪氨酸进行氧化制备。

储存分类代码

11 - Combustible Solids

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
BCCL8556
BCCK2954
BCCK7608
BCCH4437
BCCF0394

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Melanin
Riley PA
The International Journal of Biochemistry & Cell Biology, 29(11), 1235-1239 (1997)
Bovine serum albumin reverses inhibition of RT-PCR by melanin
Giambernardi TA, et al.
Biotechniques, 25(4), 564-566 (1998)
Constant rate of steady-state self-antigen trafficking from skin to regional lymph nodes
Yoshino M, et al.
International Immunology, 18(11), 1541-1548 (2006)
Justyna M Drewnowska et al.
PloS one, 10(4), e0125428-e0125428 (2015-04-25)
Although melanin is known for protecting living organisms from harmful physical and chemical factors, its synthesis is rarely observed among endospore-forming Bacillus cereus sensu lato. Here, for the first time, we reported that psychrotolerant Bacillus weihenstephanensis from Northeastern Poland can
Fengmei Zou et al.
Biomedical optics express, 1(3), 748-761 (2011-01-25)
An accurate SO(2) prediction method for using broadband continuous-wave diffuse reflectance near infrared (NIR) spectroscopy is proposed. The method fitted the NIR spectra to a Taylor expansion attenuation model, and used the simulated annealing method to initialize the nonlinear least
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Questions

1–4 of 4 Questions  

  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

      Helpful?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

  3. Can this product be dissolved in water?

    1 answer

    1. Product M8631 is not tested for solubility in water. The solubility is tested in 1N NH4OH at 20 mg/ml.

      Helpful?

  4. We have used this melanin product. Is it known whether it is in oxidized form? Any information about the exact chemical structure ?

    1 answer

    1. This synthetic melanin product was prepared by oxidation of tyrosine with hydrogen peroxide.

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