跳转至内容
Merck
所有图片(5)

文件

H9523

Sigma-Aldrich

3-(2-氨乙酸)吲哚 盐酸盐

≥98%, powder, neurotransmitter

别名:

3-(2-氨基乙基)-5 -羟基吲哚 盐酸盐, 5-羟色胺, 5-羟色胺 盐酸盐

登录查看公司和协议定价
所有图片(5)

About This Item

经验公式（希尔记法）:
C10H12N2O · HCl
CAS号:
153-98-0
分子量:
212.68
Beilstein:
3570963
MDL號碼:
MFCD00012686
分類程式碼代碼:
12352200
PubChem物質ID:
24278124
NACRES:
NA.77

product name

3-(2-氨乙酸)吲哚 盐酸盐, powder

化驗

≥98%

形狀

powder

顏色

white to off-white

mp

149-154 °C (lit.)

溶解度

H2O: 17 mg/mL
0.1 M HCl: 22 mg/mL
ethanol: 5.3 mg/mL

儲存溫度

2-8°C

SMILES 字串

Cl[H].NCCc1c[nH]c2ccc(O)cc12

InChI

1S/C10H12N2O.ClH/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10;/h1-2,5-6,12-13H,3-4,11H2;1H

InChI 密鑰

MDIGAZPGKJFIAH-UHFFFAOYSA-N

基因資訊

human ... HTR3A(3359)

正在寻找类似产品? 访问 产品对比指南

一般說明

血清素普遍存在于所有动物中。它在中枢和外周神经系统中(CAN/PNS)发挥多样功能，是一种激素和丝裂原分子，血清素由大脑中的轴突终末生产。动作电位引发血清素释放，在突触中扩散结合到突触后受体引起神经反应。血清素在发育、呼吸、体温调节、内分泌、心血管和胃肠道功能中起重要作用。还在睡眠觉醒周期、性、情绪、记忆、攻击性、痛觉、学习和认知等感知觉行为中发挥作用。血清素影响多种精神障碍，包括精神分裂、神经性厌食症、抑郁，还影响强迫症、惊恐发作和社交恐惧症等焦虑障碍。血清素水平变化与药物滥用、赌博、注意力缺陷障碍、强迫症和冲动性的冲动相关障碍或人格障碍有关。

應用

盐酸血清素用于：研究5-羟色胺受体拮抗剂调节肝脏球状体纤维化的机制，研究其对人胚胎肾脏细胞细胞外信号调节激酶(ERK)磷酸化的影响，用于结肠癌细胞系的transwell试验、愈伤试验和肿瘤同种异体移植试验

生化／生理作用

神经递质。

特點和優勢

该化合物收录于 受体分类和信号转导手册的《生物胺转运体 》页面。想要浏览手册的其他页面， 请单击此处。

準備報告

溶液需新鲜配制。

象形圖

Skull and crossbonesHealth hazard
GHS06,GHS08

訊號詞

Danger

危險聲明

H301,H361

危險分類

Acute Tox. 3 Oral - Repr. 2

儲存類別代碼

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves

分析证书(COA)

输入产品批号来搜索 分析证书(COA) 。批号可以在产品标签上"批“ （Lot或Batch）字后找到。

已有该产品？

在文件库中查找您最近购买产品的文档。

访问文档库

Sara Redenšek Trampuž et al.
Scientific reports, 14(1), 1396-1396 (2024-01-17)
Non-alcoholic steatohepatitis (NASH) is a major health problem leading to liver fibrosis and hepatocellular carcinoma, among other diseases, and for which there is still no approved drug treatment. Previous studies in animal models and in LX-2 cells have indicated a
Soaleha Shams et al.
Behavioral neuroscience, 131(6), 492-504 (2017-12-01)
Social isolation can be used to study behavioral, neural, and hormonal mechanisms that regulate interactions in social animals. Although isolation effects have been reported in social mammals and various fish species, systematic studies with isolated zebrafish are rare. Here, the
Vinay Kumar Sharma et al.
Research square (2023-02-16)
5-Hydroxy tryptamine receptor 1E (5-HTR1E) is reported to activate cAMP and ERK pathways via its ligands and binding partners, but the detailed mechanism underlying the serotonin induced 5-HTR1E signaling is still not known. In the present study, we determined the
Serotonin Receptors
Nichols David E and Nichols Charles D.
Chemical Reviews (2008)
Rhian Stavely et al.
Inflammatory bowel diseases, 24(5), 1021-1034 (2018-04-19)
Serotonin (5-hydroxytryptamine, 5-HT) has been linked with several inflammation-associated intestinal diseases, including ulcerative colitis (UC). The largest pool of 5-HT in the body is in enterochromaffin (EC) cells located throughout the intestinal tract. EC cells are mechanosensitive and detect noxious
查看所有相关文献

商品

Serotonin Synthesis & Metabolism

Serotonin is stored in cells and metabolized by MAO, influencing CNS, GI, and platelet functions.

Serotonin Synthesis & Metabolism

Serotonin is stored in cells and metabolized by MAO, influencing CNS, GI, and platelet functions.

血清素合成及代谢

血清素（5-羟色胺）主要存在于三种主要细胞类型中：i）中杻神经系统（CNS）和肠肌间神经丛中的血清素能神经元，ii）胃肠道粘膜中的肠嗜铬细胞，和iii）血小板。血清素的代谢主要通过外部线粒体膜酶单胺氧化酶（MAO）进行，它以两种分子亚型存在，分别称为MAO-A和MAO-B。

Serotonin Synthesis & Metabolism

Serotonin is stored in cells and metabolized by MAO, influencing CNS, GI, and platelet functions.

查看所有结果

我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系技术服务部门