推荐产品
生物源
mouse
共軛
unconjugated
抗體表格
purified immunoglobulin
抗體產品種類
primary antibodies
無性繁殖
TN-26, monoclonal
形狀
buffered aqueous solution
物種活性
mouse
技術
complement-mediated cytotoxicity assay: suitable
indirect immunofluorescence: suitable
同型
IgM
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
mouse ... Thy1(21838)
一般說明
单克隆抗 Thy 1.1（小鼠 IgM 同种型）来源于小鼠骨髓瘤细胞与免疫小鼠脾细胞融合产生的杂交瘤。
胸腺细胞抗原 1 (Thy 1.1) 是一种糖基磷脂酰锚定蛋白。它属于免疫球蛋白超家族。Thy 1.1 在干细胞、T 细胞和神经元中表达。
特異性
识别Thy 1.1轴承细胞，与Thy 1.2轴承细胞的交叉反应小于5%。根据对AKR / J胸腺细胞的体外细胞毒性测定，滴度为1:20,000
免疫原
AKR/J (Thy 1.1) 小鼠的胸腺细胞。
應用
小鼠源抗Thy 1.1单克隆抗体可用于免疫淘选和免疫荧光。
生化／生理作用
研究表明，缺乏蛋白质胸腺细胞抗原 1 (Thy 1.1) 的小鼠成纤维细胞数量增加。这种成分可抑制真皮成纤维细胞的增殖并增强其凋亡，从而调节细胞生长。此过程通过调节β3整合素的作用实现。
外觀
0.1 M磷酸盐缓冲液（pH 7.4，含有15 mM叠氮化钠）溶液
免責聲明
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
nwg
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Wendy A Neveu et al.
American journal of physiology. Cell physiology, 309(9), C616-C626 (2015-09-04)
Idiopathic pulmonary fibrosis is a progressive lung disease that increases in incidence with age. We identified a profibrotic lung phenotype in aging mice characterized by an increase in the number of fibroblasts lacking the expression of thymocyte differentiation antigen 1
Zhenghui Cheng et al.
BMC molecular and cell biology, 22(1), 21-21 (2021-04-09)
Schwann cells (SCs) play a crucial role in the repair of peripheral nerves. This is due to their ability to proliferate, migrate, and provide trophic support to axon regrowth. During peripheral nerve injury, SCs de-differentiate and reprogram to gain the
Yunsong Zhang et al.
Journal of molecular neuroscience : MN, 72(6), 1402-1412 (2022-05-17)
Cellular metabolism is essentially linked to tissue remodeling and organ regeneration. MOGS, a gene that encodes cellular metabolism-related protein mannosyl-oligosaccharide glucosidase, was found to be upregulated in nerve segments after peripheral nerve injury. Bioinformatic analyses identified upstream regulators of MOGS
Glial-mediated neuroprotection: Evidence for the protective role of the NO-cGMP pathway via neuron-glial communication in the peripheral nervous system.
Thippeswamy T, et al.
Glia, 49(2), 197-210 (2005)
Dongren Yang et al.
The Journal of cell biology, 168(4), 655-666 (2005-02-09)
Schwann cells form basal laminae (BLs) containing laminin-2 (Ln-2; heterotrimer alpha2beta1gamma1) and Ln-8 (alpha4beta1gamma1). Loss of Ln-2 in humans and mice carrying alpha2-chain mutations prevents developing Schwann cells from fully defasciculating axons, resulting in partial amyelination. The principal pathogenic mechanism
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