M4074

Mometasone furoate

≥98% (HPLC)

• 别名: (11β,16α)-9,21-Dichloro-17-[(2-furanylcarbonyl)oxy]-11-hydroxy-16-methylpregna-1,4-diene-3,20-dione
• 经验公式（希尔记法）: C₂₇H₃₀Cl₂O₆
• CAS号: 83919-23-7
• 分子量: 521.43
• MDL编号: MFCD00866003
• UNSPSC代码: 51111800
• PubChem化学物质编号: 329817988
• NACRES: NA.77

属性

• 质量水平: 100
• 方案: ≥98% (HPLC)
• 表单: powder
• 旋光性: [α]/D +50 to +60°, c = 0.5 in methanol
• 颜色: white to off-white
• 溶解性: DMSO: ≥20 mg/mL
• 创始人: Schering Plough
• 储存温度: 2-8°C
• SMILES字符串: C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(Cl)[C@@H](O)C[C@]2(C)[C@@]1(OC(=O)c5ccco5)C(=O)CCl
• InChI: 1S/C27H30Cl2O6/c1-15-11-19-18-7-6-16-12-17(30)8-9-24(16,2)26(18,29)21(31)13-25(19,3)27(15,22(32)14-28)35-23(33)20-5-4-10-34-20/h4-5,8-10,12,15,18-19,21,31H,6-7,11,13-14H2,1-3H3/t15-,18+,19+,21+,24+,25+,26+,27+/m1/s1
• InChI key: WOFMFGQZHJDGCX-ZULDAHANSA-N
• 基因信息: human ... NR3C1(2908)

说明

应用

Mometasone furoate has been used to study its effect on Leishmania major amastigotes.

生化/生理作用

Mometasone furoate is a 17-heterocyclic intranasal corticosteroid. It is effectively used as a first-line daily intranasal therapeutic for allergic rhinitis and nasal polyposis. Mometasone furoate is also used as an adjunct to anti-bacterials for treating acute rhinosinusitis. In addition, it relieves the symptoms of asthma in both adults and adolescents by exhibiting a broad spectrum of anti-inflammatory properties.

Mometasone furoate is an anti-inflammatory glucocorticoid.

特点和优势

This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Schering Plough. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

安全信息

• 象形图: GHS08
• 警示用语：: Danger
• 危险声明: H360D
• 预防措施声明: P201 - P202 - P280 - P308 + P313 - P405 - P501
• 危险分类: Repr. 1B
• 储存分类代码: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• 闪点(°F): Not applicable
• 闪点(°C): Not applicable