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Merck

M0883

Sigma-Aldrich

4-Methylumbelliferyl acetate

esterase substrate

别名:

MU-Ac

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About This Item

经验公式(希尔记法):
C12H10O4
CAS号:
分子量:
218.21
Beilstein:
189667
EC 号:
MDL编号:
UNSPSC代码:
12352204
PubChem化学物质编号:
NACRES:
NA.32

方案

≥98% (TLC)

表单

powder

mp

149-150 °C (lit.)

溶解性

chloroform: 100 mg/mL, clear, colorless

荧光

λex 312 nm in methanol
λex 360 nm; λem 499 nm (Reaction product)

储存温度

−20°C

SMILES字符串

CC(=O)Oc1ccc2C(C)=CC(=O)Oc2c1

InChI

1S/C12H10O4/c1-7-5-12(14)16-11-6-9(15-8(2)13)3-4-10(7)11/h3-6H,1-2H3

InChI key

HXVZGASCDAGAPS-UHFFFAOYSA-N

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象形图

Exclamation mark

警示用语:

Warning

危险声明

危险分类

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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A A Frimer et al.
Free radical biology & medicine, 20(6), 843-852 (1996-01-01)
--2-(Dimethylamino) fluorene (1a) and 5-benzoyloxy-2,3,7,8,12,13,17,18-octaethylporphyrin (4) react with superoxide anion radical (generated from KO2/18-crown-6 polyether) in aprotic media. Yet, when incorporated into the lipid bilayer of dimyristoyl phosphatidylcholine liposomes, these two substrates are inert to superoxide, generated enzymatically (xanthine oxidase/acetaldehyde)
H G Raj et al.
Teratogenesis, carcinogenesis, and mutagenesis, 21(2), 181-187 (2001-02-27)
Our earlier studies documented the ability of 7,8-diacetoxy-4-methylcoumarin (DAMC) to cause irreversible inhibition of cytochrome P-450 linked mixed function oxidases (MFO) mediated by membrane bound DAMC: protein transacetylase. Since P-450 catalyzed oxidation of benzene is crucial to its toxic effects
Enzyme kinetic studies in cell populations using fluorogenic substrates and flow cytometric techniques.
J V Watson
Cytometry, 1(2), 143-151 (1980-09-01)
M L Graber et al.
The American journal of physiology, 250(1 Pt 2), F159-F168 (1986-01-01)
Intracellular pH (pHi) of turtle bladder mucosal cells was studied by the trapped fluorescent indicator technique. Bladders efficiently accumulated and converted 4-methylumbelliferyl acetate to its pH-sensitive derivative 4-methylumbelliferone (4MU). Excited at the pH-indifferent wavelength 334 nm, bladders fluoresced a uniform
Abha Kathuria et al.
Bioorganic & medicinal chemistry, 17(4), 1550-1556 (2009-02-03)
Calreticulin Transacetylase (CRTAase) catalyzes the transfer of acetyl groups from polyphenolic acetates (PAs) to the receptor proteins and modulates their biological activities. CRTAase was conveniently assayed by the irreversible inhibition of cytosolic glutathione S-transferase (GST) by the model acetoxycoumarin, 7,8-diacetoxy-4-methylcoumarin

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