HPA003254
Anti-OLIG2 antibody produced in rabbit
Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
别名:
Anti-Class B basic helix- loop-helix protein 1, Anti-Oligo2, Anti-Oligodendrocyte transcription factor 2, Anti-Protein kinase C-binding protein 2, Anti-Protein kinase C-binding protein RACK17, Anti-bHLHB1
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About This Item
推荐产品
生物源
rabbit
品質等級
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
產品線
Prestige Antibodies® Powered by Atlas Antibodies
形狀
buffered aqueous glycerol solution
物種活性
human
加強驗證
orthogonal RNAseq
Learn more about Antibody Enhanced Validation
技術
immunoblotting: 0.04-0.4 μg/mL
immunohistochemistry: 1:2500-1:5000
免疫原序列
SPEPDDLFLPARSKGSSGSAFTGGTVSSSTPSDCPPELSAELRGAMGSAGAHPGDKLGGSGFKSSSSSTSSSTSSAAASSTKKDKKQMTEPELQQLRLKINSRERKRMHDLNI
UniProt登錄號
應用
research pathology
運輸包裝
wet ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... OLIG2(10215)
一般說明
OLIG2 (oligodendrocyte lineage transcription factor 2) is a transcription factor (TF) belonging to the basic-helix-loop-helix (bHLH) TF family. It is expressed in human glioblastoma and neural progenitor cells. It is a member of the Olig family, and has a predominant expression in ventral spinal cord of human embryo, during initial developmental stages. In spinal cord, it is essential for the maturation of oligodendrocyte progenitor cells.
免疫原
Oligodendrocyte transcription factor 2 recombinant protein epitope signature tag (PrEST)
應用
All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project and as a result, are supported by the most extensive characterization in the industry.
The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies® protocols and other useful information.
The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies® protocols and other useful information.
Anti-OLIG2 antibody produced in rabbit has been used in immunohistochemistry and western blotting.
生化／生理作用
OLIG2 (oligodendrocyte lineage transcription factor 2) is expressed in the pMN domain of the spinal cord, where the formation of motoneurons and differentiation of oligodendrocytes occur. Along with Olig1, another protein of the same family, Olig2 participates in specification of neurons, astrocytes, and oligodendrocytes. The gene is mapped to a region on chromosome 21 that has been implicated in learning deficits associated with Down syndrome. It is predominantly expressed in oligodendroglial tumors of the brain and serves as a biomarker for oligodendroglial tumor diagnosis.
特點和優勢
Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.
Every Prestige Antibody is tested in the following ways:
Every Prestige Antibody is tested in the following ways:
- IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
- Protein array of 364 human recombinant protein fragments.
聯結
Corresponding Antigen APREST84779
外觀
Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide
法律資訊
Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 1
個人防護裝備
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
其他客户在看
A Dual SILAC Proteomic Labeling Strategy for Quantifying Constitutive and Cell--Cell Induced Protein Secretion.
Stiess M, et al.
Journal of Proteome Research, 14(8), 3229-3238 (2015)
Multifocal and multicentric low-grade oligoastrocytoma in a young patient.
Grosu F, et al.
Romanian Journal of Morphology and Embryology, 58(1), 207-210 (2017)
B G Novitch et al.
Neuron, 31(5), 773-789 (2001-09-25)
Within the developing vertebrate nervous system, the mechanisms that coordinate neuronal subtype identity with generic features of neuronal differentiation are poorly defined. We show here that a bHLH protein, Olig2, is expressed selectively by motor neuron progenitors and has a
Louis Larrouquère et al.
International journal of molecular sciences, 22(19) (2021-10-14)
Glioblastoma (GBM) is the most aggressive malignant glioma, with a very poor prognosis; as such, efforts to explore new treatments and GBM's etiology are a priority. We previously described human GBM cells (R2J-GS) as exhibiting the properties of cancer stem
Lina Chakrabarti et al.
Nature neuroscience, 13(8), 927-934 (2010-07-20)
Over-inhibition is thought to be one of the underlying causes of the cognitive deficits in Ts65Dn mice, the most widely used model of Down syndrome. We found a direct link between gene triplication and defects in neuron production during embryonic
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
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