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生物来源
Pseudomonas fluorescens
质量水平
方案
≥30 % (biuret)
表单
lyophilized powder
比活
≥0.5 units/mg protein
组成
Protein, ≥30% biuret
技术
inhibition assay: suitable
储存温度
−20°C
一般描述
生化/生理作用
GABase 催化中枢神经系统中的γ-氨基丁酸（GABA）转化为琥珀酸。它用于测定各种生物学样品中的GABA水平。对羟基苯甲醛（HBA）是潜在的GABase抑制剂。[3]
单位定义
一个酶活性单位是指在pH 8.6、25°C下，每分钟将1.0 μmole的γ-氨基丁酸（GABA）转化为琥珀酸半醛、再转化为琥珀酸，并且化学计量还原1.0 μmole的NADP+所需的酶量。
外形
部分纯化的冻干粉末，含有缓冲盐和稳定剂
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
其他客户在看
Structural and Mechanistic Basis for the Inactivation of Human Ornithine Aminotransferase by (3 S,4 S)-3-Amino-4-fluorocyclopentenecarboxylic Acid
Shen S, et al.
Molecules (Basel), 28(3) (2023)
Mingu Gordon Park et al.
Journal of enzyme inhibition and medicinal chemistry, 36(1), 2016-2024 (2021-09-14)
Many studies have focussed on modulating the activity of γ-aminobutyric acid transaminase (GABA-T), a GABA-catabolizing enzyme, for treating neurological diseases, such as epilepsy and drug addiction. Nevertheless, human GABA-T synthesis and purification have not been established. Thus, biochemical and drug
Kimon-Andreas G Karatzas et al.
Applied and environmental microbiology, 76(11), 3529-3537 (2010-04-20)
It is well established that the glutamate decarboxylase (GAD) system is central to the survival of Listeria monocytogenes at low pH, both in acidic foods and within the mammalian stomach. The accepted model proposes that under acidic conditions extracellular glutamate
Nicolaie Moldovan et al.
Sensors and actuators. B, Chemical, 337 (2022-05-24)
Glutamate (GLU) and gamma-aminobutyric acid (GABA) are neurotransmitters (NTs) with an essential role in signal transmission in the brain. Brain disorders, such as epilepsy, Alzheimer's and Parkinson's diseases, and traumatic brain injury can be linked to imbalances in the GLU-GABA
A Vidal-Cros et al.
The Biochemical journal, 229(3), 675-678 (1985-08-01)
L-threo-3-Fluoroglutamate and L-erythro-3-fluoroglutamate were tested with glutamate decarboxylase from Escherichia coli. Both isomers were substrates: the threo isomer was decarboxylated into optically active 4-amino-3-fluorobutyrate, whereas the erythro isomer lost the fluorine atom during the reaction, yielding succinic semialdehyde after hydrolysis
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What is the Department of Transportation shipping information for this product?
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How do I solubilize Product No. G7509, GABase from Pseudomonas fluorescens?
1 answer-
Sigma recommends to dissolve the product with 75 mM phosphate buffer, pH 7.2, containing 25% (v/v) glycerol to a concentration of 2-5 units per mL. Keep the solution in an ice bath while using and store solution frozen. This solution may be stored frozen and thawed several times with only slight loss of activity.
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Are there any literature references that cite use of the Product No. G7509, GABase from Pseudomonas fluorescens?
1 answer-
The product is cited in the reference Sulaimana, Saba A.J., et al., J of Enz Inhib and Med Chem. 18(4), 297-301 (2003).
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What is the shelf life of the Product No.G7509, GABase from Pseudomonas fluorescens?
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Sigma recommends retesting the product 3 years after its release date. The retest date will appear on the lot specific Certificate of Analysis for the product.
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