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G6793

Sigma-Aldrich

GW7647

≥98% (HPLC)

别名:

2-(4-(2-(1-环己烷丁基)-3-环己基脲基)乙基)苯硫基)-2-甲基丙酸

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About This Item

经验公式（希尔记法）:
C29H46N2O3S
CAS号:
265129-71-3
分子量:
502.75
MDL號碼:
MFCD06798379
分類程式碼代碼:
12352200
PubChem物質ID:
24278790
NACRES:
NA.77

品質等級

100

化驗

≥98% (HPLC)

顏色

white

溶解度

DMSO: soluble 16 mg/mL
H2O: insoluble

SMILES 字串

CC(C)(Sc1ccc(CCN(CCCCC2CCCCC2)C(=O)NC3CCCCC3)cc1)C(O)=O

InChI

1S/C29H46N2O3S/c1-29(2,27(32)33)35-26-18-16-24(17-19-26)20-22-31(28(34)30-25-14-7-4-8-15-25)21-10-9-13-23-11-5-3-6-12-23/h16-19,23,25H,3-15,20-22H2,1-2H3,(H,30,34)(H,32,33)

InChI 密鑰

PKNYXWMTHFMHKD-UHFFFAOYSA-N

基因資訊

human ... PPARA(5465)

應用

GW7647已被用作过氧化物酶体增殖物激活受体α (PPAR α)配体：
  • 脱脂培养基，用于治疗原代人肝细胞
  • 测试对心肌细胞糖酵解功能的影响
  • 测试对幼鼠心脏的影响
  • 在乳腺癌MDA-MB-231细胞中激活PPAR

生化／生理作用

GW7647可降低血清甘油三酯水平，提高β-氧化相关基因的肝脏表达。GW7647与二甲双胍联合应用可提高肝脏脂肪变性或损伤情况下血清中天冬氨酸转氨酶(AST)和丙氨酸转氨酶(ALT)的水平。
强效人PPARα激动剂。用于研究人细胞中PPARα受体的生物学。

特點和優勢

该化合物在受体分类和信号转导手册的 核受体（PPAR） 页面上有详细描述。如需浏览其他手册页面，请点击此处。

法律資訊

根据Glaxo­Smith­Kline协议，仅为研究目的出售

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

分析证书(COA)

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Jun Zhang et al.
Oncotarget, 8(13), 20766-20783 (2017-02-12)
Peroxisome proliferators-activated receptors (PPARα, γ and δ) are potentially effective targets for Type 2 diabetes mellitus therapy. The severe effects of known glitazones and the successfully approved agents (saroglitazar and lobeglitazone) motivated us to study novelly potent PPARs drugs with
Yanjie Cheng et al.
Molecular therapy. Nucleic acids, 9, 195-206 (2017-12-17)
Widely varied compounds, including certain plasticizers, hypolipidemic drugs (e.g., ciprofibrate, fenofibrate, WY-14643, and clofibrate), agrochemicals, and environmental pollutants, are peroxisome proliferators (PPs). Appropriate dose of PPs causes a moderate increase in the number and size of peroxisomes and the expression
Sriram Ramanan et al.
Free radical biology & medicine, 45(12), 1695-1704 (2008-10-15)
Whole-brain irradiation (WBI) can lead to cognitive impairment several months to years after irradiation. Studies on rodents have shown a rapid and sustained increase in activated microglia (brain macrophages) following brain irradiation, contributing to a chronic inflammatory response and a
Luisa Vergori et al.
Stem cells translational medicine, 7(1), 135-145 (2017-10-29)
Metabolic pathologies such as diabetes and obesity are associated with decreased level of circulating and bone marrow (BM)-derived endothelial progenitor cells (EPCs). It is known that activation of peroxisome proliferator-activated receptor alpha (PPARα) may stimulate cell differentiation. In addition, microparticles
Yeon-Ji Kim et al.
Food research international (Ottawa, Ont.), 101, 209-217 (2017-09-25)
Chronic alcohol consumption leads to hepatic lipid accumulation and alcoholic fatty liver disease. Previously, we demonstrated that barley sprout extract, which contains saponarin as an active compound, reduces hepatic steatosis. In this study, we investigated the effect of barley sprout
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