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Merck
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文件

G6129

Sigma-Aldrich

鸟苷-3′,5′-环一磷酸 钠盐

≥99% (HPLC), powder

别名:

3′，5′-环GMP 单钠盐, 3′，5′-环磷酸鸟苷钠, cGMP, 环GMP, 鸟苷-3′,5′-环磷酸酯 单钠盐

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About This Item

经验公式（希尔记法）:
C10H11N5NaO7P
CAS号:
40732-48-7
分子量:
367.19
Beilstein:
6467425
EC號碼:
255-056-0
MDL號碼:
MFCD00038424
分類程式碼代碼:
41106305
PubChem物質ID:
24895245
NACRES:
NA.77

化驗

≥99% (HPLC)

形狀

powder

顏色

white

溶解度

H2O: 50 mg/mL

儲存溫度

−20°C

SMILES 字串

[Na+].NC1=Nc2c(ncn2[C@@H]3O[C@@H]4COP([O-])(=O)O[C@H]4[C@H]3O)C(=O)N1

InChI

1S/C10H12N5O7P.Na/c11-10-13-7-4(8(17)14-10)12-2-15(7)9-5(16)6-3(21-9)1-20-23(18,19)22-6;/h2-3,5-6,9,16H,1H2,(H,18,19)(H3,11,13,14,17);/q;+1/p-1/t3-,5-,6-,9-;/m1./s1

InChI 密鑰

KMPIYXNEROUNOG-GWTDSMLYSA-M

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相关类别

生化／生理作用

作为重要的第二信使，cGMP是细胞外信号（例如一氧化氮和利尿钠肽）的主要细胞内介质。环状GMP可与三种类型的细胞内受体蛋白相互作用：cGMP依赖性蛋白激酶、cGMP调节的通道、以及cGMP调节的环核苷酸磷酸二酯酶。cGMP水平在体内升高的主要作用是刺激cGMP依赖性蛋白激酶（PKG）。

特點和優勢

《受体分类和信号转导》手册的 磷酸二酯酶以及PKA & PKG页面有该化合物的介绍。想要浏览手册的其他页面， 请单击此处。
这种化合物是环核苷酸研究的特色产品。点击此处发现更多特色环核苷酸产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

分析证书(COA)

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C Picco et al.
The Journal of physiology, 460, 741-758 (1993-01-01)
1. The permeability of the channel activated by guanosine 3',5'-cyclic monophosphate (cGMP) to many organic monovalent cations was determined by recording macroscopic currents in excised inside-out patches of plasma membrane from isolated retinal rod outer segments of the tiger salamander.
G Colamartino et al.
The Journal of physiology, 440, 189-206 (1991-01-01)
1. Blockage and permeation of divalent cations through channels activated by guanosine 3',5'-cyclic monophosphate (cyclic GMP) were studied in membrane patches excised from retinal rods of the tiger salamander Ambystoma tigrinum by rapidly changing the ionic medium bathing the intracellular
Katja S Kroker et al.
Neurobiology of aging, 35(9), 2072-2078 (2014-04-22)
The cyclic nucleotide cGMP is an important intracellular messenger for synaptic plasticity and memory function in rodents. Therefore, inhibition of cGMP degrading phosphodiesterases, like PDE9A, has gained interest as potential target for treatment of cognition deficits in indications like Alzheimer's
You-Lin Tain et al.
Biology of reproduction, 92(1), 7-7 (2014-11-15)
Nitric oxide (NO) deficiency induced by the NO synthase (NOS) inhibitor N(G)-nitro-L-arginine-methyl ester (L-NAME) resulted in hypertension. L-citrulline (CIT) can be converted to L-arginine to generate NO. We examined whether maternal CIT supplementation can prevent L-NAME-induced programmed hypertension. Pregnant Sprague-Dawley
Brandon A Kemp et al.
Circulation research, 115(3), 388-399 (2014-06-07)
Compound 21 (C-21) is a highly selective nonpeptide AT2 receptor (AT2R) agonist. To test the hypothesis that renal proximal tubule AT2Rs induce natriuresis and lower blood pressure in Sprague-Dawley rats and mice. In rats, AT2R activation with intravenous C-21 increased
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