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G7504

Sigma-Aldrich

鸟苷 3',5'-环单磷酸

≥98% (HPLC), powder, intracellular mediator

别名:

环化鸟嘌呤核苷酸, 环鸟苷酸

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About This Item

经验公式（希尔记法）:
C10H12N5O7P
CAS号:
7665-99-8
分子量:
345.21
EC 号:
231-641-6
MDL编号:
MFCD00070129
UNSPSC代码:
41106305
PubChem化学物质编号:
24895309
NACRES:
NA.77

产品名称

鸟苷 3',5'-环单磷酸, ≥98% (HPLC), powder

质量水平

200

方案

≥98% (HPLC)

表单

powder

颜色

white

溶解性

0.2 M NaHCO3: 50 mg/mL

储存温度

−20°C

SMILES字符串

NC1=NC(=O)c2ncn(C3OC4COP(O)(=O)OC4C3O)c2N1

InChI

1S/C10H12N5O7P/c11-10-13-7-4(8(17)14-10)12-2-15(7)9-5(16)6-3(21-9)1-20-23(18,19)22-6/h2-3,5-6,9,16H,1H2,(H,18,19)(H3,11,13,14,17)

InChI key

ZOOGRGPOEVQQDX-UHFFFAOYSA-N

相关类别

生化/生理作用

作为一种重要的第二信使，cGMP 是细胞外信号（如一氧化氮和利钠肽）的主要细胞内介质。环 GMP 与三种类型的细胞内受体蛋白相互作用：cGMP 依赖性蛋白激酶、cGMP 调节的通道和 cGMP 调节的环核苷酸磷酸二酯酶。体内 cGMP 水平升高的主要作用是刺激 cGMP 依赖性蛋白激酶 (PKG)。

特点和优势

该化合物是 ADME Tox 和环核苷酸研究的特色产品。发现更多特色 ADME Tox 和环核苷酸产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。

象形图

Exclamation mark
GHS07

警示用语：

Warning

危险声明

H315,H319,H335

危险分类

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

储存分类代码

11 - Combustible Solids

WGK

WGK 3

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000423154
0000423152
0000423152
0000423154
0000407640

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Lasse H Hansen et al.
The Journal of biological chemistry, 294(34), 12567-12578 (2019-06-13)
Atrial natriuretic peptide (ANP) is a peptide hormone that in response to atrial stretch is secreted from atrial myocytes into the circulation, where it stimulates vasodilatation and natriuresis. ANP is an important biomarker of heart failure where low plasma concentrations
Jeanette Erdmann et al.
Nature, 504(7480), 432-436 (2013-11-12)
Myocardial infarction, a leading cause of death in the Western world, usually occurs when the fibrous cap overlying an atherosclerotic plaque in a coronary artery ruptures. The resulting exposure of blood to the atherosclerotic material then triggers thrombus formation, which
Juliane W Schott et al.
Molecular therapy. Methods & clinical development, 14, 134-147 (2019-07-25)
Ex vivo retroviral gene transfer into CD34+ hematopoietic stem and progenitor cells (HSPCs) has demonstrated remarkable clinical success in gene therapy for monogenic hematopoietic disorders. However, little attention has been paid to enhancement of culture and transduction conditions to achieve reliable
Raquel Maeso-Díaz et al.
Aging and disease, 10(4), 684-698 (2019-08-24)
Advanced chronic liver disease (aCLD) represents a major public health concern. aCLD is more prevalent and severe in the elderly, carrying a higher risk of decompensation. We aimed at understanding how aging may impact on the pathophysiology of aCLD in
Minsuk Kim et al.
Nature medicine, 19(5), 567-575 (2013-04-02)
Glucagon-like peptide-1 receptor (GLP-1R) agonists exert antihypertensive actions through incompletely understood mechanisms. Here we demonstrate that cardiac Glp1r expression is localized to cardiac atria and that GLP-1R activation promotes the secretion of atrial natriuretic peptide (ANP) and a reduction of
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