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生物源
human
品質等級
重組細胞
expressed in E. coli
化驗
>97% (SDS-PAGE)
形狀
lyophilized powder
效力
28 ng/mL
分子量
19 kDa by SDS-PAGE
包裝
pkg of 25 μg
儲存條件
avoid repeated freeze/thaw cycles
技術
cell culture | mammalian: suitable
雜質
endotoxin, tested
UniProt登錄號
儲存溫度
−20°C
基因資訊
human ... FGF10(2255)
一般說明
FGF10 (fibroblast growth factor 10) is a member of the FGF protein family, which is a mitogen of epithelial origin and has a paracrine activity. It is produced by mesenchymal lineage cells, and acts as a ligand for FGFR, most notably FGFR2b, which is expressed by epithelial cells.
應用
Fibroblast Growth Factor-10 human is suitable for culturing of HUVEC cell line (human umbilical vein endothelial cells) to determine the anti-angiogenic properties of sFLT-1 (soluble fms-related tyrosine kinase-1).
生化／生理作用
FGF10 (fibroblast growth factor 10) is involved in cell growth, morphogenesis and embryogenesis. It plays an essential role in initiating the formation of limb bud, lung morphogenesis and brain formation during embryogenesis. It acts as a mitogen, where it facilitates the regeneration of epithelia post-bladder urothelial injury. Thus, it might have future applications during bladder transplantation. Studies in Japanese population show that polymosphisms- rs339501, rs12517396, and rs10462070 are linked with severe myopia, and might act as susceptibility factors for the same. In lung cancer cells, FGFR4 reduces the stem cell/self-renewal property of cancer cells, and makes them more susceptible to chemotherapy.
外觀
Lyophilized from a 0.2 μm filtered solution in 20 mM MOPS, 50 mM sodium sulfate, 1 mM DTT, 0.5 mM EDTA, pH 7.2, containing 50 μg bovine serum albumin per 1 μg cytokine.
分析報告
The biological activity is measured by its ability to stimulate the proliferation of a monkey epithelial cell line 4MBr-5.
儲存類別代碼
13 - Non Combustible Solids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
其他客户在看
Poopak Farnia et al.
International journal of clinical and experimental medicine, 8(1), 1526-1533 (2015-03-19)
The soluble vascular endothelial growth factor receptor-1 (VEGFR1) or sFLT-1 has important role in antiangiogenesis. In this study, the increase expression and production of sFLT-1 fragment by newly designed ChPL-NPs nanoparticles (chitosan-protein lipid) using Chinese hamster ovary cell line (CHO)
Seyung S Chung et al.
In vitro cellular & developmental biology. Animal, 49(10), 746-751 (2013-08-21)
Fibroblast growth factor 10 (FGF10) is required for embryonic epidermal morphogenesis including brain development, lung morphogenesis, and initiation of limb bud formation. In this study, we investigated the role of FGF10 as a lead induction factor for stem cell differentiation
S Tagashira et al.
Gene, 197(1-2), 399-404 (1997-10-23)
We cloned the mouse homolog of FGF10, which was recently reported as a new member of the FGF family. The predicted molecular mass of this molecule is 23.6 kDa, and both nucleotide and amino acid sequences show high degrees of
H Ohuchi et al.
Development (Cambridge, England), 124(11), 2235-2244 (1997-06-01)
Vertebrate limb formation has been known to be initiated by a factor(s) secreted from the lateral plate mesoderm. In this report, we provide evidence that a member of the fibroblast growth factor (FGF) family, FGF10, emanates from the prospective limb
Masao Yoshida et al.
Molecular vision, 19, 2321-2329 (2013-11-23)
The fibroblast growth factor 10 (FGF10) gene polymorphism rs339501 was previously reported to be associated with high myopia in a Chinese population. In the present study, we investigated whether FGF10 polymorphisms are associated with extreme myopia in a Japanese population
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Role of growth factors in stem cell differentiation and various growth factors for your research at sigmaaldrich.com
Role of growth factors in stem cell differentiation and various growth factors for your research at sigmaaldrich.com
Role of growth factors in stem cell differentiation and various growth factors for your research at sigmaaldrich.com
Role of growth factors in stem cell differentiation and various growth factors for your research at sigmaaldrich.com
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