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化驗
≥97% (HPLC)
形狀
powder
分子量
437.55
儲存條件
(Keep container tightly closed in a dry and well-ventilated place)
技術
activity assay: suitable
溶解度
acetic acid: 20 mg/mL, clear, colorless
儲存溫度
−20°C
SMILES 字串
CSCC[C@H](NC=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(O)=O
InChI
1S/C21H31N3O5S/c1-14(2)11-17(23-19(26)16(22-13-25)9-10-30-3)20(27)24-18(21(28)29)12-15-7-5-4-6-8-15/h4-8,13-14,16-18H,9-12H2,1-3H3,(H,22,25)(H,23,26)(H,24,27)(H,28,29)/t16-,17-,18-/m0/s1
InChI 密鑰
PRQROPMIIGLWRP-BZSNNMDCSA-N
基因資訊
human ... FPR1(2357)
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Amino Acid Sequence
NFor-Met-Leu-Phe
一般說明
N-甲酰-甲硫氨酰-亮氨酰-苯丙氨酸是（N-Formyl-Met-Leu-Phe, fMLP）一种趋化因子肽，可作用于多形核白细胞（PMN）、中性粒细胞等
研究领域：细胞信号传导
研究领域：细胞信号传导
應用
N-甲酰-甲硫氨酰-亮氨酰-苯丙氨酸已用于：
- 中性粒细胞Zigmond室法趋化分析中的梯度构建
- 中性粒细胞趋化测定
- 确定MAPK活化蛋白激酶-2（MAPKAPK-2）和/或p38是否参与由N-甲酰-甲硫氨酰-亮氨酰-苯丙氨酸刺激的人多形核白细胞（PMN）的信号传导途径。
生化／生理作用
N-甲酰-甲硫氨酰-亮氨酰-苯丙氨酸可诱导磷酸肌醇3-激酶γ（PI3K）γ-/- 中性粒细胞的趋化、促进F-肌动蛋白的粘附和聚合，以及Fcγ受体介导的吞噬作用和细胞内Ca2+ 的释放。它可作为炎症因子，激活多形核白细胞（PMNs），且不会产生5-羟基山梨酸（5-HETE）和白三烯B4 （LTB4）。其对中性粒细胞的影响，以及腺苷酸环化酶的抑制效果可被百日咳毒素所抑制。
有效的趋化肽。诱导巨噬细胞的代谢爆发，并伴随着呼吸速率的增加、溶酶体酶的分泌以及超氧阴离子的产生。
白细胞趋化的强效诱导剂和巨噬细胞的激活剂。 研究发现结合甲酰基肽的受体存在于吞噬性中性粒细胞上，并且最近已在肠粘膜细胞上发现。
抗體
产品编号
说明
价格
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
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