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Merck
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文件

47729

Sigma-Aldrich

N-甲酰-甲硫氨酰-亮氨酰-苯丙氨酸

≥99.0% (TLC), BioXtra

别名:

N-甲酰-L-甲硫氨酰-L-亮氨酰-L-苯丙氨酸, fMLF, fMLP（用词错误，但已被广泛使用）, 趋化肽

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About This Item

经验公式（希尔记法）:
C21H31N3O5S
CAS号:
59880-97-6
分子量:
437.55
Beilstein:
2315783
MDL號碼:
MFCD00036780
分類程式碼代碼:
12352209
PubChem物質ID:
57651094
NACRES:
NA.26

product name

N-甲酰-甲硫氨酰-亮氨酰-苯丙氨酸, BioXtra, ≥99.0% (TLC)

產品線

BioXtra

化驗

≥99.0% (TLC)

形狀

powder

顏色

white

溶解度

DMF: 50 mg/mL, clear, colorless

應用

cell analysis

儲存溫度

2-8°C

SMILES 字串

CSCC[C@H](NC=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(O)=O

InChI

1S/C21H31N3O5S/c1-14(2)11-17(23-19(26)16(22-13-25)9-10-30-3)20(27)24-18(21(28)29)12-15-7-5-4-6-8-15/h4-8,13-14,16-18H,9-12H2,1-3H3,(H,22,25)(H,23,26)(H,24,27)(H,28,29)/t16-,17-,18-/m0/s1

InChI 密鑰

PRQROPMIIGLWRP-BZSNNMDCSA-N

基因資訊

human ... FPR1(2357)

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相关类别

Amino Acid Sequence

NFor-Met-Leu-Phe

應用

1. 4th and 5th applications do not have access
2. 3rd application is not relevant

生化／生理作用

N-甲酰基-Met-Leu-Phe是一种有效的趋化肽和甲酰肽受体（FPR）激动剂，可诱导巨噬细胞的代谢爆发，伴随呼吸四氯、溶酶体酶分泌和超氧阴离子产生的增加。
有效的趋化肽。诱导巨噬细胞的代谢爆发，并伴随着呼吸速率的增加、溶酶体酶的分泌以及超氧阴离子的产生。

包裝

无底玻璃瓶。内含物在插入的融合锥体内。

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

分析证书(COA)

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Astrid L Voskamp et al.
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Allergic bronchopulmonary aspergillosis (ABPA) often presents with persistently uncontrolled asthma despite the use of corticosteroids and antifungal therapy. Omalizumab is a humanized anti-IgE monoclonal antibody currently used to treat severe asthma. The aim was to assess the clinical and immunologic
C Dahlgren et al.
Blood, 95(5), 1810-1818 (2000-02-26)
A D-methionine-containing peptide, Trp-Lys-Tyr-Met-Val-D-Met-NH(2) (WKYMVm), featuring a unique receptor specificity was investigated with respect to its ability to activate neutrophil effector functions. The peptide was found to be more potent than the N-formylated peptide N-formyl-Met-Leu-Phe (fMLF) at inducing neutrophil chemotaxis
J James B Edelman et al.
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Persistent alteration to host polymorphonuclear cell (PMN) physiology has been demonstrated after cardiac surgery performed with cardiopulmonary bypass (CPB). However, to date, PMN physiology and function beyond the first 24 h have not been investigated after cardiac surgery performed without
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Journal of immunology (Baltimore, Md. : 1950), 189(9), 4657-4665 (2012-09-25)
Superoxide anion production by the neutrophil NADPH oxidase plays a key role in host defense; however, excessive superoxide production is believed to participate to inflammatory reactions. Neutrophils express several TLR that recognize a variety of microbial motifs or agonists. The
Isaac M Chiu et al.
Nature, 501(7465), 52-57 (2013-08-24)
Nociceptor sensory neurons are specialized to detect potentially damaging stimuli, protecting the organism by initiating the sensation of pain and eliciting defensive behaviours. Bacterial infections produce pain by unknown molecular mechanisms, although they are presumed to be secondary to immune
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