D9160

1-甘露糖野尻霉素 盐酸盐

• 别名: 1-Deoxymannojirimycin HCl, 1,5-Dideoxy-1,5-imino-D-mannitol hydrochloride
• 经验公式（希尔记法）: C₆H₁₃NO₄ · HCl
• CAS号: 73465-43-7
• 分子量: 199.63
• MDL號碼: MFCD00083611
• 分類程式碼代碼: 51102829
• PubChem物質ID: 24894265
• NACRES: NA.76

属性

• 形狀: powder
• 顏色: white to off-white
• 溶解度: H₂O: 10 mg/mL
• 抗生素活性譜: viruses
• 作用方式: enzyme | inhibits
• 儲存溫度: 2-8°C
• SMILES 字串: Cl.OC[C@H]1NC[C@@H](O)[C@@H](O)[C@@H]1O
• InChI: 1S/C6H13NO4.ClH/c8-2-3-5(10)6(11)4(9)1-7-3;/h3-11H,1-2H2;1H/t3-,4-,5-,6-;/m1./s1
• InChI 密鑰: ZJIHMALTJRDNQI-MVNLRXSJSA-N

说明

一般說明

Chemical structure: glucosamine

應用

1-Deoxymannojirimycin (DMM) hydrochloride is an inhibitor of N-linked glycosylation and has antiviral activity. Derivatives of deoxymannojirimycin may have anti-HIV activity. It has been used for treatment of T lymphocytes and to study it′s effect on allogeneic cytotoxic T lymphocytes (CTL). It is used for studies on Golgi-mediated glycoprotein processing.

生化／生理作用

1-Deoxymannojirimycin is a mannosidase I inhibitor, alters cell-surface complex carbohydrate structure as assayed by PHA-L binding, and increases high mannose structures as indicated by the increased Con-A binding.

Selectively inhibits Golgi associated α(1→2) mannosidase and for studies on Golgi-mediated glycoprotein processing.

安全信息

• 象形圖: GHS07
• 訊號詞: Warning
• 危險聲明: H302 + H312 + H332
• 防範說明: P261 - P264 - P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312
• 危險分類: Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 個人防護裝備: dust mask type N95 (US), Eyeshields, Gloves