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Merck

C8661

Sigma-Aldrich

氯化钴 六水合物

BioReagent, suitable for cell culture, suitable for insect cell culture

别名:

氯化钴 六水合物

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About This Item

线性分子式:
CoCl2 · 6H2O
CAS号:
分子量:
237.93
EC 号:
MDL编号:
UNSPSC代码:
12352207
PubChem化学物质编号:
NACRES:
NA.71
表单:
powder
价格与库存信息目前不能提供

蒸汽压

40 mmHg ( 0 °C)

质量水平

产品线

BioReagent

表单

powder

技术

cell culture | insect: suitable
cell culture | mammalian: suitable

SMILES字符串

O.O.O.O.O.O.Cl[Co]Cl

InChI

1S/2ClH.Co.6H2O/h2*1H;;6*1H2/q;;+2;;;;;;/p-2

InChI key

GFHNAMRJFCEERV-UHFFFAOYSA-L

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应用

  • Synthesis, Characterization, and Biological Activities of Novel Vanadium(IV) and Cobalt(II) Complexes:研究新型钴(II)复合物的合成及生物应用潜力,特别是它们在各种细胞模型中的生物活性(Damena T, Zeleke D, Desalegn T, et al. 2022.ACS Omega)。

警示用语:

Danger

危险分类

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 1B Inhalation - Eye Dam. 1 - Muta. 2 - Repr. 1B - Resp. Sens. 1 - Skin Sens. 1

储存分类代码

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Tugba Kilic et al.
Scientific reports, 8(1), 9402-9402 (2018-06-22)
Nanoscale extracellular vesicles (EVs) including exosomes (50-150 nm membrane particles) have emerged as promising cancer biomarkers due to the carried genetic information about the parental cells. However the sensitive detection of these vesicles remains a challenge. Here we present a label-free
Shahna Shahulhameed et al.
Frontiers in neuroscience, 13, 1445-1445 (2020-03-03)
The detailed mechanisms underlying oxidative stress that leads to neuroinflammation and neurodegeneration in retinal vascular conditions, including diabetic retinopathy, retinopathy of prematurity etc., remain largely unexplored mainly due to a lack of suitable disease models that can simulate the inherent
Baoan Hong et al.
International journal of biological sciences, 15(3), 587-597 (2019-02-13)
Tribbles pseudokinase 3 (TRIB3) is a member of the mammalian pseudokinase tribbles family and is involved in multiple biological processes. However, the role of TRIB3 in renal cell carcinoma (RCC) remains unclear. In this study, we aimed to elucidate the
Seo-Hyun Choi et al.
Biochimica et biophysica acta. Gene regulatory mechanisms, 1862(8), 771-785 (2019-07-05)
Overexpressed Solute Carrier Family 16 Member 3 (SLC16A3, also called MCT4) plays a critical role in hypoxic cancer cell growth and proliferation, by expelling glycolysis-derived lactate across the plasma membrane. However, how SLC16A3 expression is regulated, under hypoxic conditions, is
Yuan Zhang et al.
Clinica chimica acta; international journal of clinical chemistry, 489, 203-211 (2017-12-11)
Accumulated data indicate that placental hypoxia is implicated in the pathogenesis of preeclampsia (PE). Tight junction (TJ) is important structure that sustains normal placental barrier function, its dysregulation under hypoxia has been observed. This study was designed to explore hypoxia-induced

Questions

1–3 of 3 Questions  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

      Helpful?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

  3. Can C8661 be used in normoxia to induce hypoxia?

    1 answer
    1. CoCl2 is generally known to replace Fe2+ that binds to prolyl hydroxylase (PHD), which degrades hypoxia-inducible factor‑1α (HIF-1a) under normoxic conditions. This binding blocks the activity of PHD and subsequently upregulates the level of HIF-1a to simulate hypoxic conditions.

      Helpful?

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