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N6136

Sigma-Aldrich

氯化镍(II) 六水合物

BioReagent, suitable for cell culture

别名:

NiCl2.6H2O, Nickel chloride hexahydrate, Nickel dichloride hexahydrate

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About This Item

线性分子式:
NiCl2 · 6H2O
CAS号:
7791-20-0
分子量:
237.69
MDL编号:
MFCD00149809
UNSPSC代码:
12352207
PubChem化学物质编号:
24897771
NACRES:
NA.71
价格与库存信息目前不能提供

等级

reagent

产品线

BioReagent

表单

powder

技术

cell culture | mammalian: suitable

SMILES字符串

[H]O[H].[H]O[H].[H]O[H].[H]O[H].[H]O[H].[H]O[H].Cl[Ni]Cl

InChI

1S/2ClH.Ni.6H2O/h2*1H;;6*1H2/q;;+2;;;;;;/p-2

InChI key

LAIZPRYFQUWUBN-UHFFFAOYSA-L

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相关类别

应用

六水氯化镍 (II)：
  • 用于制备镍镀层溶液，用于在合成多壁碳纳米管微电机过程中还原碳层内部对镍进行静电镀膜 [1]
  • 用于筛选金属对血管内皮细胞的炎症效应 [2]
  • 作为人工脑脊液（ACSF）的添加剂，用于分析海马脑片中兴奋性突触后电流（EPSPs）[3]

生化/生理作用

镍 (Ni) 是人体必需的微量元素，对 DNA、RNA 和蛋白质的结构和功能均具有重要作用。其在较高浓度时对肾、肺及心血管系统有毒性作用。[4]镍与致癌作用有关。[5]Ni 2 + 离子是一种诱裂剂。[6]镍离子 (Ni2 + ) 是一种非特异性电压门控钙通道阻滞剂。[7]

警示用语：

Danger

危险分类

Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 1A Inhalation - Muta. 2 - Repr. 1B - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT RE 1 Inhalation

靶器官

Lungs

储存分类代码

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000382512
0000354115
0000354114
0000332404
0000339091

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Nonrandom chromosomal alterations in nickel-transformed Chinese hamster embryo cells
Conway K and Costa M
Cancer Research, 49(21), 6032-6038 (1989)
Genetic and epigenetic mechanisms in metal carcinogenesis and cocarcinogenesis: nickel, arsenic, and chromium
Salnikow K and Zhitkovich A
Chemical Research in Toxicology, 21(1), 28-44 (2007)
Studies on the genotoxic effect of nickel chloride in mice and the possible protective role of soybean seeds extracts
Fahmy MA, et al.
Global Journal of Pharmacology, 8(4), 625-634 (2014)
Surfactant-Free beta-Galactosidase Micromotors for ?On-The-Move? Lactose Hydrolysis
Maria-Hormigos R, et al.
Advances in Functional Materials, 28(25), 1704256-1704256 (2018)
Functional coupling of Cav2.3 and BK potassium channels regulates action potential repolarization and short-term plasticity in the mouse hippocampus
Gutzmann JJ, et al.
Frontiers in Cellular Neuroscience, 13(3), 492-499 (2019)
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Questions

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  1. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  2. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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