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Merck
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C5857

Sigma-Aldrich

CA-074 甲基酯

≥99% (TLC)

别名:

(L-3-反式-(丙基氨基甲酰)环氧乙烷-2-甲酰基)-L-异亮氨酰-L-脯氨酸甲酯

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About This Item

经验公式（希尔记法）:
C19H31N3O6
CAS号:
147859-80-1
分子量:
397.47
MDL编号:
MFCD03452890
UNSPSC代码:
12352108
PubChem化学物质编号:
329775104
NACRES:
NA.77

生物来源

synthetic (organic)

质量水平

100

方案

≥99% (TLC)

表单

solid

储存温度

−20°C

SMILES字符串

CCCNC(=O)[C@H]1O[C@@H]1C(=O)N[C@@H](C(C)CC)C(=O)N2CCC[C@H]2C(=O)OC

InChI

1S/C19H31N3O6/c1-5-9-20-16(23)14-15(28-14)17(24)21-13(11(3)6-2)18(25)22-10-7-8-12(22)19(26)27-4/h11-15H,5-10H2,1-4H3,(H,20,23)(H,21,24)/t11?,12-,13-,14-,15-/m0/s1

InChI key

XGWSRLSPWIEMLQ-RQLZCWDZSA-N

相关类别

应用

使用CA-074甲酯用作心肌细胞、HeLa细胞和胰腺癌PANC-1细胞中的组织蛋白酶B抑制剂。

生化/生理作用

CA-074甲酯是CA-074的细胞渗透性类似物。它是组织蛋白酶B尤其胞内型的抑制剂，可通过酯酶作用在细胞内转化为活性CA-074。CA-074甲酯还可抑制组织蛋白酶L。

特点和优势

这种化合物是凋亡研究的特色产品。点击此处发现更多特色凋亡产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
MKCV4462
MKCS3393
MKCS0909
MKCN3559
MKCM9154

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D J Buttle et al.
Archives of biochemistry and biophysics, 299(2), 377-380 (1992-12-01)
The specificity of compound CA074 [N-(L-3-trans-propylcarbamoyloxirane-2-carbonyl)-L-isoleucyl-L-pro line] for the inactivation of cathepsin B was quantified in in vitro measurements with cysteine endopeptidases from cattle, it being found that the compound is a very rapid inactivator of cathepsin B (rate constant
Cathepsin B deficiency attenuates cardiac remodeling in response to pressure overload via TNF-alpha/ASK1/JNK pathway
Wu QQ, et al.
American Journal of Physiology. Heart and Circulatory Physiology, 308(9), H1143-H1154 (2015)
Preliminary research on the pathological role of cathepsin-B in subcutaneous heteroplastic pancreatic carcinoma in nude mice
Zhang C, et al.
Chinese Medical Journal (English Edition), 122(20), 2489-2496 (2009)
An intracellular form of cathepsin B contributes to invasiveness in cancer
Szpaderska AM and Frankfater A
Cancer Research, 61(8), 3493-3500 (2001)
Chee Fan Tan et al.
Cells, 9(5) (2020-05-30)
Studies have shown that the process of extracellular vesicles (EVs) secretion and lysosome status are linked. When the lysosome is under stress, the cells would secrete more EVs to maintain cellular homeostasis. However, the process that governs lysosomal activity and
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