价格与库存信息目前不能提供
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产品名称
CA-074 Me, CA-074 Me, CAS 147859-80-1, is a cell-permeable analog of CA-074 that acts as an irreversible inhibitor of intracellular cathepsin B.
质量水平
方案
≥98% (HPLC)
表单
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
颜色
white
溶解性
DMSO: 10 mg/mL
运输
ambient
储存温度
−20°C
一般描述
CA-074（目录编号205530）的细胞可渗透类似物，可作为细胞内组织蛋白酶B的不可逆抑制剂。据报道在啮齿动物模型中抑制骨吸收，并在体外显示出抑制B16黑色素瘤细胞侵袭的作用。
CA-074（目录编号205530）的细胞可渗透类似物，可作为细胞内组织蛋白酶B的不可逆抑制剂。
生化/生理作用
主要靶标
组织蛋白酶B
组织蛋白酶B
产物不与ATP竞争。
可逆：否
细胞可渗透性：是
靶标IC50：2.24 nM，针对组织蛋白酶B
警告
毒性：标准处理（A）
重悬
复溶后，等分并冷冻保存（-20°C）。储备液在-20°C条件下可稳定保存3个月。
其他说明
Sever, N., et al. 2002.Biol. Chem.383, 839.
Authier, F., et al. 1999.J. Biol. Chem.274, 33723.
Hill, P.A., et al. 1994.J. Cell Biochem.56, 118.
Buttle, D.J., et al. 1992.Arch.Biochem.Biophys.299, 377.
Authier, F., et al. 1999.J. Biol. Chem.274, 33723.
Hill, P.A., et al. 1994.J. Cell Biochem.56, 118.
Buttle, D.J., et al. 1992.Arch.Biochem.Biophys.299, 377.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Carolina Duarte et al.
Journal of cellular and molecular medicine, 26(10), 2841-2851 (2022-04-17)
Emerging studies indicate that intracellular eukaryotic ceramide species directly activate cathepsin B (CatB), a lysosomal-cysteine-protease, in the cytoplasm of osteoclast precursors (OCPs) leading to elevated RANKL-mediated osteoclastogenesis and inflammatory osteolysis. However, the possible impact of CatB on osteoclastogenesis elevated by
Michael C Yoon et al.
Biochemistry, 61(4), 228-238 (2022-02-05)
CA-074 is a selective inhibitor of cathepsin B, a lysosomal cysteine protease. CA-074 has been utilized in numerous studies to demonstrate the role of this protease in cellular and physiological functions. Cathepsin B in numerous human disease mechanisms involves its
Katia Fettucciari et al.
Cellular and molecular life sciences : CMLS, 79(8), 442-442 (2022-07-22)
Clostridioides difficile infection (CDI) causes nosocomial/antibiotic-associated gastrointestinal diseases with dramatically increasing global incidence and mortality rates. The main C. difficile virulence factors, toxins A and B (TcdA/TcdB), cause cytopathic/cytotoxic effects and inflammation. We demonstrated that TcdB induces caspase-dependent, mitochondria-independent enteric
Qi Feng Lin et al.
Journal of virology, 97(10), e0082823-e0082823 (2023-09-25)
Reoviruses infect many mammals and are widely studied as a model system for enteric viruses. However, most of our reovirus knowledge comes from laboratory strains maintained on immortalized L929 cells. Herein, we asked whether naturally circulating reoviruses possess the same
Soo-Jin Oh et al.
Cell death discovery, 9(1), 100-100 (2023-03-23)
While the mechanism of lipotoxicity by palmitic acid (PA), an effector of metabolic stress in vitro and in vivo, has been extensively investigated, molecular details of lipotoxicity are still not fully characterized. Since recent studies reported that PA can exert
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