所有图片(1)
About This Item
经验公式（希尔记法）:
C18H29N3O6
CAS号:
分子量:
383.44
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
推荐产品
生物来源
synthetic (organic)
质量水平
方案
≥98% (HPLC)
表单
powder
溶解性
methanol: 1 mg/mL, clear, colorless
储存温度
−20°C
SMILES字符串
CCCNC(=O)[C@H]1O[C@@H]1C(=O)N[C@@H]([C@H](C)CC)C(=O)N2CCC[C@H]2C(O)=O
InChI
1S/C18H29N3O6/c1-4-8-19-15(22)13-14(27-13)16(23)20-12(10(3)5-2)17(24)21-9-6-7-11(21)18(25)26/h10-14H,4-9H2,1-3H3,(H,19,22)(H,20,23)(H,25,26)/t10?,11-,12-,13-,14-/m0/s1
InChI key
ZEZGJKSEBRELAS-NSIINPIOSA-N
应用
CA-074 已被用作组织蛋白酶 B 抑制剂：
- 利用 HeLa 细胞研究其对携带 R642M 和 N714K 的 S 蛋白的假型病毒的影响
- 确定自噬在葡萄糖缺乏（GD）诱导的损伤中的作用
- 研究其暴露于组织蛋白酶 B（CATB）对神经元功能的影响
生化/生理作用
CA-074 是组织蛋白酶 B 的有效和选择性抑制剂。它有助于研究组织蛋白酶 B 在体内的生物学功能。研究表明，CA-074 在还原条件下也能抑制组织蛋白酶 L。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
其他客户在看
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A series of new epoxysuccinyl peptides were designed and synthesized to develop a specific inhibitor of cathepsin B. Of these compounds, N-(L-3-trans-ethoxycarbonyloxirane-2-carbonyl)-L-isoleucyl-L-proli ne (compound CA-030) and N-(L-3-trans-propylcarbamoyloxirane-2-carbonyl)-L-isoleucyl-L-prol ine (compound CA-074) were the most potent and specific inhibitors of cathepsin B
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Proceedings of the National Academy of Sciences of the United States of America, 102(30), 10493-10498 (2005-07-16)
The Josephin domain plays an important role in the cellular functions of ataxin-3, the protein responsible for the neurodegenerative Machado-Joseph disease. We have determined the solution structure of Josephin and shown that it belongs to the family of papain-like cysteine
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