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Merck
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主要文件

C2313

Sigma-Aldrich

化合物 48/80

powder,  hypotensive agent

别名:

Poly-p-methoxyphenethylmethylamine

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About This Item

UNSPSC代码:
41106300
NACRES:
NA.77
价格与库存信息目前不能提供

产品名称

化合物 48/80,

表单

powder

质量水平

溶解性

H2O: 50 mg/mL

储存温度

−20°C

相关类别

一般描述

化合物48/80,是一种N-甲基p-甲氧基苯乙基胺和甲醛缩合产物。[1]

应用

48/80化合物可用来:
  • 刺激血细胞释放组胺,从而通过ELISA和流式细胞仪测定[2]
  • 诱发肥大细胞脱粒[3]
  • 诱发小鼠过敏性活动、皮炎、瘙痒和炎症[4]

生化/生理作用

化合物48/80是一种低血压药,[1]促进组胺释放。[2][1]C 48/80降低了 Styela plicata血细胞的吞噬能力。[2]C 48/80 促进肥大细胞脱粒。[2][3]它抑制钙调蛋白,磷脂酶C,内质网(ER)Ca2+磷酸酶和激活G蛋白。[1]

制备说明

N-甲基-p-甲氧基苯乙基胺和甲醛缩合产物。

象形图

Skull and crossbones

警示用语:

Danger

危险声明

危险分类

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral

储存分类代码

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Differential activation of the PI 3-kinase effectors AKT/PKB and p70 S6 kinase by compound 48/80 is mediated by PKC alpha
Byrne RD, et al.
Cellular Signalling, 19(2), 321-329 (2007)
Y Koibuchi et al.
European journal of pharmacology, 115(2-3), 163-170 (1985-09-24)
Compound 48/80 and 14C-labeled compound 48/80 were synthesized, and fractionated by thin-layer chromatography into 14 components (A-N) with various histamine releasing activities and different Ca2+ requirements for their actions. The histamine release induced from rat mast cells in vitro by
C Bronner et al.
Biochimica et biophysica acta, 920(3), 301-305 (1987-08-15)
Compound 48/80 inhibited phosphatidylinositol-specific phospholipase C activity from human platelets. Whereas 1 microgram/ml of compound 48/80 slightly stimulated Ca2+-dependent phospholipase A2, higher concentrations led to dose-dependent inhibition of this platelet enzyme. This biphasic effect was confirmed with phospholipases A2 purified
Radhika Palkar et al.
The Journal of investigative dermatology, 138(6), 1391-1399 (2017-12-31)
Cooling or the application of mentholated liniments to the skin has been used to treat itch for centuries, yet remarkably little is known about how counter-stimuli such as these induce itch relief. Indeed, there is no clear consensus in the
Development of a short-term canine full-thickness skin organ culture method under serum-free conditions
Abramo F, et al.
American Journal of Animal and Veterinary Sciences, 11(2), 61-69 (2016)

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