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Merck

A1520

Sigma-Aldrich

α-Amylase Inhibitor

≥200 inhibitor U/mg protein (using porcine pancreatic α-amylase), ≥1000 inhibitor U/mg protein (using human salivary α-amylase), lyophilized powder

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About This Item

MDL號碼:
分類程式碼代碼:
12352202
NACRES:
NA.77

product name

α-淀粉酶抑制剂 来源于小麦 (小麦种子), Type I, lyophilized powder

生物源

Triticum estivum

品質等級

種類

Type I

形狀

lyophilized powder

比活性

≥1000 inhibitor U/mg protein (using human salivary α-amylase)
≥200 inhibitor U/mg protein (using porcine pancreatic α-amylase)

成份

Protein, 35-65% biuret

儲存溫度

−20°C

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一般說明

α-淀粉酶是糖苷内切酶,属于糖基水解酶家族13 (1-3)。

應用

目前已经采用小麦(小麦种子)来源α-淀粉酶抑制剂确定其对唾液腺 (SG) 淀粉酶活性的影响。此外,这种抑制剂还被用来抑制粉虱提取物的活性。

生化/生理作用

α-淀粉酶可以水解α-(1,4)-D-糖苷键。其可参与淀粉和糖原分解。抑制这种酶的做法可用作龋齿、糖尿病、肥胖症和牙周疾病的治疗策略。
人唾液α-淀粉酶的竞争性抑制剂。KI = 2.9 nM,而KM为5.9 mM(按每摩尔α-1,4-连接的麦芽糖残基计算)。

單位定義

25°C预孵育后,一单位抑制剂可使两单位α-淀粉酶(A0521)活性降低50%。

外觀

冻干粉,含如磷酸钠之类的缓冲盐。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


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A review of alpha-amylase inhibitors on weight loss and glycemic control in pathological state such as obesity and diabetes
Mahmood N
Comparative clinical pathology, 25(6), 1253-1264 (2016)
alpha-Amylase inhibitors: a review of raw material and isolated compounds from plant source
Sales PM, et al.
J. Pharm. Pharm. Sci., 15(1), 141-183 (2012)
Frauke Schocker et al.
International archives of allergy and immunology, 174(1), 17-25 (2017-09-28)
Little is known about breast milk as a vehicle for tolerance development or sensitization to peanuts very early in life. Thus, well-characterized and highly sensitive detection systems for the reliable determination of peanut allergens in breast milk are mandatory. For
Demonstration and preliminary characterization of -amylase in the sweetpotato whitefly, Bemisia tabaci (Aleyrodidae: Homoptera)
Cohen AC and Hendrix DL
Comparative Biochemistry and Physiology (1994)
Partial characterization of alpha-amylase in the salivary glands of Lygus hesperus and L. lineolaris
Zeng F and Cohen AC
Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology, 126(1), 9-16 (2000)

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