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Merck

A0384

Sigma-Aldrich

魁蛤素 硫酸盐

别名:

1,4-双胍基丁烷 硫酸盐

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About This Item

经验公式(希尔记法):
C6H16N6 · H2O4S
CAS号:
分子量:
270.31
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77
价格与库存信息目前不能提供

生物源

synthetic (organic)

品質等級

化驗

≥98% (TLC)

形狀

powder

mp

>280 °C

溶解度

1 M NaOH: 50 mg/mL, clear to slightly hazy, colorless to faintly yellow

SMILES 字串

OS(O)(=O)=O.NC(=N)NCCCCNC(N)=N

InChI

1S/C6H16N6.H2O4S/c7-5(8)11-3-1-2-4-12-6(9)10;1-5(2,3)4/h1-4H2,(H4,7,8,11)(H4,9,10,12);(H2,1,2,3,4)

InChI 密鑰

RWTGFMPOODRXIM-UHFFFAOYSA-N

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應用

Arcaine sulfate salt has been used as an N-methyl-d-aspartate (NMDA) receptor effector/antagonist:
  • to evaluate its effects on the acquisition of electrical kindling of the amygdala[1]
  • to compare its effects with agmatine and MK801 on NMDA- or glutamate-induced neuronal damage[2]
  • to study its effects on cell-free translation of synthetic polynucleotide[3]

生化/生理作用

Arcaine sulfate salt (1,4-diguanidinobutane), a polyamine,[3] is an antagonist of the polyamine binding site of the N-methyl-d-aspartate (NMDA) receptor.[4] Arcaine, an agmatine analog,[2] along with ifenprodil, might have a possibility for therapeutic management in epileptic disorders.[1]

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Min-Ching Kuo et al.
The European journal of neuroscience, 27(7), 1731-1738 (2008-03-29)
Recent evidence indicates that the mature central visual system retains a higher degree of plasticity than traditionally assumed. However, little is known regarding the neuromodulatory factors that influence plasticity in the adult primary visual cortex (V1). We investigated the role
Nandkishor Ramdas Kotagale et al.
Behavioural brain research, 213(2), 161-174 (2010-05-11)
Agmatine [2-(4-aminobutyl)guanidine] is an endogenous amine proposed as a neurotransmitter/neuromodulator that binds to multiple target receptors in brain. Besides, many central and peripheral functions, agmatine have been implicated in the process of drug addiction. The purpose of the present study
Koichi Tan-No et al.
Pain, 113(3), 301-309 (2005-01-22)
Intrathecal (i.t.) administration into mice of N-ethylmaleimide (NEM), a cysteine protease inhibitor, produced a characteristic behavioral response, the biting and/or licking of the hindpaw and the tail along with slight hindlimb scratching directed toward the flank. The behavior induced by
Keli Camera et al.
Psychopharmacology, 192(4), 457-464 (2007-02-24)
The polyamines putrescine, spermine, and spermidine are a group of aliphatic amines that physiologically modulate the N-methyl-D-aspartate (NMDA) receptor, a glutamate receptor implicated in memory formation. Given the potential application of these drugs in the treatment of memory disorders, we
I J Reynolds
The Journal of pharmacology and experimental therapeutics, 255(3), 1001-1007 (1990-12-01)
This study investigated the interaction between the polyamines spermine and spermidine and the N-methyl-D-aspartate (NMDA) receptor by using (+)-[3H]-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-im ine maleate ([3H]MK801) binding to well washed rat brain membranes. The actions of arcaine, agmatine, diethylenetriamine and 1,8-octanediamine as polyamine antagonists

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