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R0300000

醋酸维生素 A

European Pharmacopoeia (EP) Reference Standard

别名:

视黄醇乙酸酯, 维生素 A 醋酸酯, 醋酸维生素 A

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About This Item

经验公式（希尔记法）:
C22H32O2
CAS号:
127-47-9
分子量:
328.49
Beilstein:
1915439
MDL编号:
MFCD00019413
UNSPSC代码:
41116107
PubChem化学物质编号:
329823984
NACRES:
NA.24
价格与库存信息目前不能提供

生物来源

synthetic

等级

pharmaceutical primary standard

Agency

EP

API类

retinyl compounds

表单

solid

制造商/商品名称

EDQM

技术

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

mp

57-58 °C

应用

pharmaceutical (small molecule)

包装形式

neat

储存温度

−20°C

SMILES字符串

CC1=C(/C=C/C(C)=C/C=C/C(C)=C/COC(C)=O)C(C)(C)CCC1

InChI

1S/C22H32O2/c1-17(9-7-10-18(2)14-16-24-20(4)23)12-13-21-19(3)11-8-15-22(21,5)6/h7,9-10,12-14H,8,11,15-16H2,1-6H3/b10-7+,13-12+,17-9+,18-14+

InChI key

QGNJRVVDBSJHIZ-QHLGVNSISA-N

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相关类别

一般描述

本品根据现行药典要求提供和指定。所有为支持本产品而提供的信息，包括SDS和任何产品信息小册子，均根据现行药典制定和发布。更多信息和支持请访问药典颁发机构网站。

视黄醇乙酸酯属于视黄醇类，与维生素A在化学上相关。视黄醇用于通过口服和局部给药治疗痤疮和牛皮癣。

应用

本欧洲药典参考标准仅用于欧洲药典中明确规定的用途。

包装

本品按照现行药典要求提供。有关当前单位数量，请见EDQM 参考目录。

其他说明

可能适用相应的销售限制。

象形图

Health hazard
GHS08

警示用语：

Danger

危险声明

H360D,H413

危险分类

Aquatic Chronic 4 - Repr. 1B

储存分类代码

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Simultaneous determination of retinol acetate, retinol palmitate, cholecalciferol, α-tocopherol acetate and alphacalcidol in capsules by non-aqueous reversed-phase HPLC and column backflushing
Wielinski S and Olszanowski A
Chromatographia, 50(1-2), 109-112 (1999)
Sunatda Arayachukeat et al.
International journal of pharmaceutics, 404(1-2), 281-288 (2010-11-26)
Retinyl acetate (RA) loaded polymeric nanoparticle (NP) carriers were prepared using two different single polymers, ethyl cellulose (EC) and poly (ethylene glycol)-4-methoxycinnamoylphthaloylchitosan (PCPLC). The stability of RA to aqueous solution and UVA light was significantly improved when encapsulated with PCPLC
Avash J Singh et al.
Pediatric research, 67(6), 619-623 (2010-03-11)
Chronic lung disease (CLD) is a major cause of long-term morbidity in extremely LBW infants with respiratory distress syndrome. Parenteral vitamin A administration decreases the risk of CLD. We tested the hypothesis that intratracheal vitamin A administration with surfactant is
Ling Zhang et al.
Nature, 464(7291), 1058-1061 (2010-03-30)
Cancer chemoprevention uses natural, synthetic, or biological substances to reverse, suppress, or prevent either the initial phase of carcinogenesis or the progression of neoplastic cells to cancer. It holds promise for overcoming problems associated with the treatment of late-stage cancers.
Tadao Maeda et al.
Investigative ophthalmology & visual science, 50(10), 4917-4925 (2009-06-06)
Evaluate the efficacy of potential therapeutics in Rdh8(-/-)Abca4(-/-) mice, a rodent model of human age-related macular degeneration (AMD). Therapeutic efficacy of several antioxidant agents (ascorbic acid, alpha-lipoic acid, alpha-tocopherol, Mn(III)-tetrakis(4-benzoic acid)-porphyrin, and butylated hydroxytoluene), an immunosuppressive agent with antivascular endothelial
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实验方案

HPLC Analysis of Vitamins, Fat Soluble (A and E), on SUPELCOSIL™ LC-18

Separation of δ-Tocopherol, analytical standard; Retinyl acetate; (+)-γ-Tocopherol; α-Tocopherol, ≥95.5%; Retinol; Vitamin A (acetate), meets USP testing specifications.

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