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Merck

L0380000

左旋咪唑 盐酸盐

European Pharmacopoeia (EP) Reference Standard

别名:

(−)-四咪唑 盐酸盐, L(−)- 2,3,5,6-四氢-6-苯基咪唑并[2,1-b]噻唑 盐酸盐, 左旋咪唑 盐酸盐, (S)-(−)-6-苯基-2,3,5,6-四氢咪唑并[2,1-b]噻唑 盐酸盐

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About This Item

经验公式(希尔记法):
C11H12N2S · HCl
CAS号:
分子量:
240.75
Beilstein:
4358988
EC 号:
MDL编号:
UNSPSC代码:
41116107
PubChem化学物质编号:
NACRES:
NA.24
价格与库存信息目前不能提供

等级

pharmaceutical primary standard

API类

levamisole

制造商/商品名称

EDQM

mp

228-230 °C

应用

pharmaceutical (small molecule)

包装形式

neat

SMILES字符串

Cl.C1CN2C[C@@H](N=C2S1)c3ccccc3

InChI

1S/C11H12N2S.ClH/c1-2-4-9(5-3-1)10-8-13-6-7-14-11(13)12-10;/h1-5,10H,6-8H2;1H/t10-;/m1./s1

InChI key

LAZPBGZRMVRFKY-HNCPQSOCSA-N

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一般描述

本品按现行药典规定交付。所有为支持本产品而提供的信息,包括SDS和任何产品信息单均由药典颁发机构制定并发布。 如需进一步信息和支持,请访问现行药典网站。

应用

盐酸左旋咪唑EP参考标准品的预期用途是欧洲药典规定的实验室测试。

生化/生理作用

根据一些可控因素,同时显示免疫刺激和免疫抑制作用。治疗蛔虫病(钩虫感染)非常有效。可用于结肠直肠癌的化疗,可能是由于其刺激IL-1 产生和巨噬细胞的直接激活。

包装

本品按照现行药典要求提供。有关当前单位数量,请见EDQM 参考目录

其他说明

销售限制可能适用。

象形图

Skull and crossbones

警示用语:

Danger

危险声明

预防措施声明

危险分类

Acute Tox. 3 Oral

储存分类代码

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable


历史批次信息供参考:

分析证书(COA)

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Anders N Hansen et al.
PloS one, 7(9), e45405-e45405 (2012-10-02)
Inhibition of angiogenesis is a promising addition to current cancer treatment strategies. Neutralization of vascular endothelial growth factor by monoclonal antibodies is clinically effective but may cause side effects due to thrombosis. Low molecular weight angiogenesis inhibitors are currently less
Lauren Strazzula et al.
Journal of the American Academy of Dermatology, 69(6), 954-959 (2013-10-01)
Levamisole is present as a contaminant or additive in most cocaine sold in the United States. Cases of agranulocytosis attributed to levamisole-tainted cocaine have been widely described. A vasculopathic reaction to levamisole has also been reported; however, diagnostic features such as
Bashir A Lone et al.
Tropical animal health and production, 45(3), 743-749 (2012-10-16)
The aim of this study was to evaluate the anthelmintic and antimicrobial efficacy of Euphorbia helioscopia crude extracts. A worm motility inhibition assay and egg hatch assay were used for in vitro study, and a faecal egg count reduction assay
Jonathan Graf
Current opinion in rheumatology, 25(1), 50-55 (2012-12-01)
Cocaine use is associated with several rheumatic syndromes. This review summarizes these clinical manifestations and highlights recent developments linked to levamisole-adulterated cocaine. Cocaine use has been linked to several distinctive syndromes that can be difficult to distinguish from idiopathic rheumatic
Kelly R Magliocca et al.
Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 71(3), 487-492 (2013-01-10)
Systemic complications of levamisole-adulterated cocaine (LAC) use have recently been described. The objective of this review is to increase awareness of these manifestations among oral and maxillofacial surgeons. LAC exposure through inhalation, nasal insufflation, or injection can induce cutaneous vasculopathy

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