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Merck

Y0000047

左旋咪唑

European Pharmacopoeia (EP) Reference Standard

别名:

(−)-四咪唑 盐酸盐, L(−)- 2,3,5,6-四氢-6-苯基咪唑并[2,1-b]噻唑 盐酸盐, 左旋咪唑 盐酸盐, (S)-(−)-6-苯基-2,3,5,6-四氢咪唑并[2,1-b]噻唑 盐酸盐

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About This Item

经验公式(希尔记法):
C11H12N2S · HCl
CAS号:
分子量:
240.75
Beilstein:
4358988
MDL號碼:
分類程式碼代碼:
41116107
PubChem物質ID:
NACRES:
NA.24

等級

pharmaceutical primary standard

API 家族

levamisole

製造商/商標名

EDQM

mp

228-230 °C

應用

pharmaceutical (small molecule)

格式

neat

儲存溫度

2-8°C

SMILES 字串

Cl.C1CN2C[C@@H](N=C2S1)c3ccccc3

InChI

1S/C11H12N2S.ClH/c1-2-4-9(5-3-1)10-8-13-6-7-14-11(13)12-10;/h1-5,10H,6-8H2;1H/t10-;/m1./s1

InChI 密鑰

LAZPBGZRMVRFKY-HNCPQSOCSA-N

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一般說明

本品按现行药典规定交付。所有为支持本产品而提供的信息,包括SDS和任何产品信息单均由药典颁发机构制定并发布。 如需进一步信息和支持,请访问现行药典网站。

應用

用于系统适用性的盐酸左旋咪唑EP 参考标准品设计用于欧洲药典规定的实验室测试。

生化/生理作用

根据一些可控因素,同时显示免疫刺激和免疫抑制作用。治疗蛔虫病(钩虫感染)非常有效。可用于结肠直肠癌的化疗,可能是由于其刺激IL-1 产生和巨噬细胞的直接激活。

包裝

本品按照现行药典要求提供。有关当前单位数量,请见EDQM 参考目录

其他說明

可能适用相应的销售限制。

象形圖

Skull and crossbones

訊號詞

Danger

危險聲明

危險分類

Acute Tox. 3 Oral

儲存類別代碼

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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Kelly R Magliocca et al.
Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 71(3), 487-492 (2013-01-10)
Systemic complications of levamisole-adulterated cocaine (LAC) use have recently been described. The objective of this review is to increase awareness of these manifestations among oral and maxillofacial surgeons. LAC exposure through inhalation, nasal insufflation, or injection can induce cutaneous vasculopathy
M P Myklebust et al.
British journal of cancer, 107(10), 1684-1691 (2012-10-27)
The aim of this study was to investigate the value of the cyclin D1 isoforms D1a and D1b as prognostic factors and their relevance as predictors of response to adjuvant chemotherapy with 5-fluorouracil and levamisole (5-FU/LEV) in colorectal cancer (CRC).
Xingxin Li et al.
Annals of hematology, 92(9), 1239-1247 (2013-04-27)
The appropriate management of patients with moderate aplastic anemia (mAA) remains to be unclear and controversial. A cohort of 118 patients with mAA received a novel immunosuppressive strategy of cyclosporine alternately combined with levamisole (CSA and LMS regimen), which included
Ana Mbokeleng Tsotetsi et al.
Tropical animal health and production, 45(3), 751-761 (2012-10-16)
The present study was conducted to determine the prevalence and distribution of gastrointestinal helminths, to detect the presence of anthelmintic resistance in livestock from small-scale farms and to determine the level of helminthosis awareness among small-scale farmers in Gauteng Province
Annemarie Rosan Kreeftmeijer-Vegter et al.
Expert opinion on drug delivery, 10(3), 293-300 (2013-01-08)
To develop an oral solid dosage form of levamisole suitable for the paediatric population in terms of dose accuracy, palatability, stability and ease of administration. Small undividable tablets (Ø5 - 8 mm) in four different strengths were manufactured to allow

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