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Merck

A1300000

维生素C

European Pharmacopoeia (EP) Reference Standard

别名:

L -抗坏血酸, 维他命C, 抗坏血病因子, 维生素C

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About This Item

经验公式(希尔记法):
C6H8O6
CAS号:
分子量:
176.12
Beilstein:
84272
EC 号:
MDL编号:
UNSPSC代码:
41116107
PubChem化学物质编号:
NACRES:
NA.24
价格与库存信息目前不能提供

生物来源

synthetic

等级

pharmaceutical primary standard

Agency

EP Reference standard

API类

ascorbic acid

表单

solid

制造商/商品名称

EDQM

技术

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

mp

190-194 °C (dec.)

应用

pharmaceutical (small molecule)

包装形式

neat

储存温度

2-8°C

SMILES字符串

OC([C@]([C@@H](O)CO)([H])O1)=C(O)C1=O

InChI

1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-10H,1H2/t2-,5+/m0/s1

InChI key

CIWBSHSKHKDKBQ-JLAZNSOCSA-N

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一般描述

本品按现行药典规定交付。所有为支持本产品而提供的信息,包括SDS和任何产品信息单均由药典颁发机构制定并发布。如需进一步信息和支持,请访问现行药典网站。

应用

抗坏血酸EP参考标准的预期用途是欧洲药典中明确规定的用途。也用于通过色谱法[1][2]和分光光度法[3]技术对药物制剂中的分析物进行测定。

包装

本品按照现行药典要求提供。有关当前单位数量,请见EDQM 参考目录

其他说明

可能适用相应的销售限制。

储存分类代码

11 - Combustible Solids

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Spectrophotometric determination of L-ascorbic acid in pharmaceuticals
Szpikowska-Sroka B and Poledniok J
Journal of Analytical Chemistry, 66(10), 941-941 (2011)
Reversed-phase ion-pair HPLC determination of some water-soluble vitamins in pharmaceuticals
Ivanovic D, et al.
Journal of Pharmaceutical and Biomedical Analysis, 18(6), 999-1004 (1999)
Ascorbic acid
European Pharmacopoeia Commission and European Directorate for the Quality of Medicines & Healthcare
European pharmacopoeia, 18(6), 6868-6869 (2019)
Vitamin C: One compound, several uses. Advances for delivery, efficiency and stability
Carita AC, et al.
Nanomedicine: Nanotechnology, Biology, and Medicine, 31(2), 102117-102117 (2019)
First bioarchaeological evidence of probable scurvy in Southeast Asia: multifactorial etiologies of vitamin C deficiency in a tropical environment
Halcrow SE, et al.
International Journal of Paleopathology, 5(1), 63-71 (2014)

Questions

1–3 of 3 Questions  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

      Helpful?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

  3. I want to ask if the ascorbic acid, product A1300000 is delivered as powder and how many grams are in one bottle? Could you send me an example of a CoA? Has it be dried before usage as we would like to use it as standard for titer determination of Iodine?

    1 answer
    1. This is a product of the European Pharmacopoeia. Each vial contains 70 mg of Ascorbic acid in powder form. Please visit the European Pharmacopeia website for more information and download the leaflet: https://crs.edqm.eu/db/4DCGI/leaflet?leaflet=A1300000_5.pdf

      Helpful?

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