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product name
离子霉素，游离酸，Streptomyces conglobatus, Ionomycin, Free Acid, Streptomyces conglobatus, CAS 56092-81-0, is a highly specific for divalent cations and more effective than A23187 (Cat. No. 100105) as a mobile ion carrier for Ca2+.
品質等級
化驗
≥90% (HPLC)
形狀
waxy solid
製造商／商標名
Calbiochem®
儲存條件
OK to freeze
protect from light
溶解度
DMSO: 10 mg/mL
methanol: 10 mg/mL
運輸包裝
ambient
儲存溫度
2-8°C
InChI
1S/C41H72O9/c1-25(21-29(5)34(43)24-35(44)30(6)22-27(3)20-26(2)14-15-38(46)47)12-11-13-28(4)39(48)31(7)36(45)23-33-16-18-41(10,49-33)37-17-19-40(9,50-37)32(8)42/h11,13,24-33,36-37,39,42-43,45,48H,12,14-23H2,1-10H3,(H,46,47)/b13-11+,34-24-/t25-,26-,27+,28-,29-,30+,31+,32-,33?,36+,37?,39-,40+,41+/m1/s1
InChI 密鑰
PGHMRUGBZOYCAA-OJFQOPKISA-N
一般說明
对二价阳离子具有高度特异性（Ca2+ > Mg2+ >> Sr2+ = Ba2+）。比抗生素A23187作为Ca2+的移动离子载体更有效。在pH 7和9.5之间与Ca2+的络合，在紫外线范围内产生了显著的吸光值；然而，相比于A23817（货号100105），它是非荧光的。可用于研究Ca2+跨生物膜的运输以及细胞质游离Ca2+的测量。在胚胎皮质神经元中诱导凋亡神经元退化。还可在成熟的伯基特淋巴瘤细胞系的G1间隔期诱导细胞周期阻滞。
对二价阳离子具有高度特异性，并且是比 A23187（货号 100105）更有效的 Ca2+ 移动离子载体。在 pH 7 至 9.5 之间与 Ca2+ 形成复合物。与A23187相比，它没有荧光。可用于研究Ca2+跨生物膜的运输以及细胞质游离Ca2+的测量。诱导胚胎皮质神经元的凋亡神经元变性，并诱导成熟的伯基特淋巴瘤细胞系中 G1 期的细胞周期停滞。
最大吸收 （280 nm，MeOH）：18,600 M-1cm-1。
生化／生理作用
产物不与ATP竞争。
可逆：否
细胞渗透性：否
首要靶标
Ca2+的移动离子载体
Ca2+的移动离子载体
包裝
用惰性气体包装
警告
毒性：有害（C）
重構
在重悬后存放于冰箱（4°C）。储备液可在4°C最长稳定1年。
其他說明
Aagaard-Tillery, K.M., and Jelinek, D.F.1995.J. Immunol.155, 3297.
Takei, N., and Endo, Y. 1994.Brain Res. 652, 65.
Dupuy d’Angeac, A., et al. 1993.J. Cell Physiol.154, 44.
Lee, H.C.1993.J. Biol. Chem.268, 293.
Kuznetsov, G., et al. 1992.J. Biol. Chem. 267, 3932.
Toeplitz, B.K., et al. 1979.J. Am. Chem. Soc.101, 3344.
Liu, C.M., and Hermann, T.E.1978.J. Biol. Chem.253, 5892.
Takei, N., and Endo, Y. 1994.Brain Res. 652, 65.
Dupuy d’Angeac, A., et al. 1993.J. Cell Physiol.154, 44.
Lee, H.C.1993.J. Biol. Chem.268, 293.
Kuznetsov, G., et al. 1992.J. Biol. Chem. 267, 3932.
Toeplitz, B.K., et al. 1979.J. Am. Chem. Soc.101, 3344.
Liu, C.M., and Hermann, T.E.1978.J. Biol. Chem.253, 5892.
法律資訊
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
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