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Merck

B6542

Sigma-Aldrich

布雷菲德菌素 A

≥99% (HPLC and TLC), BioXtra, for molecular biology

别名:

γ,4-二羟基-2-(6-羟基-1-庚烯基)-4-环戊烯丁烯酸λ-内酯, Ascotoxin, BFA, 布雷菲德菌素 A, 烟碱

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About This Item

经验公式(希尔记法):
C16H24O4
CAS号:
分子量:
280.36
Beilstein:
25191
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.52

生物源

Penicillium brefeldianum

品質等級

等級

for molecular biology

產品線

BioXtra

化驗

≥99% (HPLC and TLC)

形狀

powder

分子量

280.36

溶解度

DMSO: 10 mg/mL (Store stock solutions at -20 °C)

抗生素活性譜

neoplastics

作用方式

protein synthesis | interferes

儲存溫度

2-8°C

SMILES 字串

C[C@H]1CCC\C=C\[C@@H]2C[C@H](O)C[C@H]2[C@H](O)\C=C\C(=O)O1

InChI

1S/C16H24O4/c1-11-5-3-2-4-6-12-9-13(17)10-14(12)15(18)7-8-16(19)20-11/h4,6-8,11-15,17-18H,2-3,5,9-10H2,1H3/b6-4+,8-7+/t11-,12+,13-,14+,15+/m0/s1

InChI 密鑰

KQNZDYYTLMIZCT-KQPMLPITSA-N

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一般說明

化学结构:大环内酯
布雷菲德菌素可诱导CtBP1/BARS蛋白的ADP核糖基化,从而调节胞内运输和分泌蛋白从内质网到高尔基体的运动。

應用

适用于分泌蛋白和细胞内转运机制的分子生物学研究

生化/生理作用

布雷菲德菌素A(BFA)是一种会破坏高尔基体的结构和功能的真菌代谢产物。BFA是鞘磷脂循环的一种激活剂。已在人类肿瘤细胞中观察到了布雷菲德菌素A介导的细胞凋亡。

原則

布雷菲德菌素是一种真菌代谢产物,可通过破坏高尔基体来破坏真核细胞中的蛋白质分泌。它不会影响蛋白质合成过程。

象形圖

Skull and crossbones

訊號詞

Danger

危險聲明

防範說明

危險分類

Acute Tox. 3 Oral

儲存類別代碼

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Faceshields, Gloves


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Y Misumi et al.
The Journal of biological chemistry, 261(24), 11398-11403 (1986-08-25)
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