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Merck
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文件

171260

Sigma-Aldrich

Dorsomorphin

≥95% (HPLC), solid, AMPK inhibitor, Calbiochem

别名:

AMPK抑制剂,化合物C

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About This Item

经验公式(希尔记法):
C24H25N5O
分子量:
399.49
MDL號碼:
分類程式碼代碼:
12352200
NACRES:
NA.77

product name

AMPK抑制剂,化合物C, AMPK Inhibitor, Compound C, CAS 866405-64-3, is a cell-permeable compound that inhibits KDR/VEGFR2, ALK2/BMPR-I, and AMPK kinase activities (IC₅₀ = 25.1, 148, and 234.6 nM, respectively).

品質等級

化驗

≥95% (HPLC)

形狀

solid

製造商/商標名

Calbiochem®

儲存條件

OK to freeze
protect from light

顏色

light yellow

溶解度

2% HCl: 10 mg/mL
2% acetic acid: 10 mg/mL
methanol: 3 mg/mL
DMSO: 4 mg/mL

運輸包裝

ambient

儲存溫度

2-8°C

InChI

1S/C24H25N5O/c1-2-12-28(13-3-1)14-15-30-22-6-4-19(5-7-22)21-16-26-24-23(17-27-29(24)18-21)20-8-10-25-11-9-20/h4-11,16-18H,1-3,12-15H2

InChI 密鑰

XHBVYDAKJHETMP-UHFFFAOYSA-N

一般說明

一种细胞可透过性吡唑并嘧啶化合物,可抑制KDR/VEGFR2、ALK2/BMPR-1、AMPK激酶活性(IC50 = 25.1、148和234.6 nM),而对对ALK5/TGFβR-I、ZAPK、Syk、PKCθ、PKA或JAK3的作用却大大降低或几乎没有。研究表明,可阻断斑马鱼活体胚胎中BMP途径依赖性背腹发育(EC100 = 2.5 µ)和VEGF信号转导依赖性肌间血管形成(EC50 = 5 µM)。也可以10 mM的DMSO溶液(货号171261)提供。

生化/生理作用

主要靶标
AMPK
产品与ATP竞争。
可逆性:是
细胞渗透性:是
阻断斑马鱼活体胚胎中BMP途径依赖性背腹发育的EC100 = 2.5 µM;阻断VEGF信号转导依赖性肌间血管形成的EC50 = 5 µM
靶标IC50:抑制KDR/VEGFR2、ALK2/BMPR-1、AMPK激酶活性分别为25.1、148和234.6 nM

包裝

用惰性气体包装

警告

毒性:标准处理(A)

重構

溶解后,等分并冷冻保存(-20°C)。储备溶液在-20°C下可稳定保存至多3个月。

其他說明

Hao, J., et al. 2010.ACS Chem.Biol.5, 245.
Yu, P.B., et al. 2008. Nat. Chem. Biol4, 33.
Kim, E.K., et al. 2004.J. Biol. Chem.279, 19970.
Lee, M., et al. 2003.J. Biol. Chem.278, 39653.
Inoki, K., et al. 2003.Cell115, 577.
Fryer, L.G., 2002.FEBS Lett.531, 189.
Zhou, G., et al. 2001.J. Clin. Invest.108, 1167.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3


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