推荐产品
品質等級
化驗
≥95% (HPLC)
形狀
powder
製造商/商標名
Calbiochem®
儲存條件
OK to freeze
protect from light
顏色
dark red
溶解度
DMSO: 50 mg/mL
運輸包裝
ambient
儲存溫度
2-8°C
一般說明
一种细胞可渗透的羟吲哚化合物,可选择性抑制BCL6的转录抑制活性(在基于293T的报告基因分析中,在50 µM时抑制约70%),但不是其他三个BTB/POZ(bric-a-brac tramtrack broad Complex/痘病毒锌指)家族成员Kaiso,HIC1和PLZF,通过BTB结构域直接BCL6结合(Kd = 138 µM)并阻断辅阻遏物BBD-(BCL6结合域)介导BCL6相互作用(IC50 = 212 µM & Ki = 147 µM,与SMRT-BBD肽竞争性结合),导致BCL依赖性DLBCL(弥漫性大B细胞淋巴瘤)中BCL6靶基因上调,但不依赖BCL的Toledo和OCI-Ly4细胞系。在体外显示出对DLBCL细胞系(IC50为24至936 µM)以及原代人DLBCL细胞的抗增殖活性,并在体内抑制小鼠中BCL依赖性肿瘤的生长(第9天为对照肿瘤大小的<40%;50 mg/kg/天,通过i.p.)。
包裝
用惰性气体包装
警告
毒性:标准处理(A)
重構
复溶后,等分并冷冻保存(-20°C)。储备液在-20°C条件下可稳定保存3个月。
其他說明
Cerchietti, L.C., et al. 2010.Cancer Cell17, 400.
法律資訊
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
儲存類別代碼
11 - Combustible Solids
水污染物質分類(WGK)
WGK 3
閃點(°F)
Not applicable
閃點(°C)
Not applicable
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