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Merck
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17-218

Sigma-Aldrich

Ras激活检测试剂盒

别名:

Ras Activity Assay

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About This Item

UNSPSC代码:
12161503
eCl@ss:
32161000
NACRES:
NA.84

制造商/商品名称

Upstate®

质量水平

100

技术

activity assay: suitable

NCBI登记号

NM_001085049.1
NM_012219.3

UniProt登记号

O14807

运输

dry ice

基因信息

human ... MRAS(22808)

一般描述

肌肉RAS癌基因同源物（MRAS）在心血管疾病中起关键作用。该MRAS基因编码GTP结合蛋白的ras超家族的一员。MRAS存在于所有组织中，特别是心血管系统中。它参与信号转导，包括细胞生长和分化。

包装

试剂盒容量：30次测定

组分

Ras检测试剂（Raf-1 RBD，琼脂糖）（目录号14-278）

Anti-Ras，克隆RAS10（目录号05-516）

100X GTPγS，10mM（目录号20-176）

100X GDP，100mM（目录号20-177）

Mg2+裂解/洗涤缓冲液，5X（目录号20-168）

质量

该试剂盒从已装有GTPγS的HeLa细胞裂解物中沉淀出Ras-GTP。使用1 μg/ml抗Ras克隆RAS10通过蛋白质免疫印迹检测沉淀的Ras-GTP

联系

替代：SGT435

法律信息

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

免责声明

除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。

象形图

CorrosionEnvironment
GHS05,GHS09

警示用语：

Danger

危险声明

H318,H410

危险分类

Aquatic Acute 1 - Aquatic Chronic 2 - Eye Dam. 1

储存分类代码

10 - Combustible liquids

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Shin-ichiro Miura et al.
Biochemical and biophysical research communications, 306(4), 924-929 (2003-06-25)
Since we recently reported that high density lipoprotein, which contains the bioactive lipid sphingosine-1-phosphate (S1P) [Arterioscler. Thromb. Vasc. Biol. 23 (2003) 802], induced human coronary artery endothelial cell (HCEC) tube formation mediated by a Ras/Raf/ERK (extracellular signal-activated kinase) pathway, we
J Kim et al.
The Journal of biological chemistry, 276(22), 19102-19110 (2001-03-23)
AMP-activated protein kinase (AMPK) is tightly regulated by the cellular AMP:ATP ratio and plays a central role in the regulation of energy homeostasis. Previously, AMPK was reported to phosphorylate serine 621 of Raf-1 in vitro. In the present study, we
Michael R Bennett et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 23(18), 7207-7217 (2003-08-09)
Neurofibromatosis type 1 (NF1) patients are predisposed to learning disabilities, macrocephaly, and brain tumors as well as abnormalities on magnetic resonance imaging that are postulated to result from abnormal myelination. Here we show that Nf1+/- spinal cords in adult mice
Shin Onodera et al.
The Journal of biological chemistry, 277(10), 7865-7874 (2001-12-26)
Neutral matrix metalloproteinases (MMPs) play an important role in bone matrix degradation accompanied by bone remodeling. We herein show for the first time that macrophage migration inhibitory factor (MIF) up-regulates MMP-13 (collagenase-3) mRNA of rat calvaria-derived osteoblasts. The mRNA up-regulation
Shin-Ichiro Miura et al.
Atherosclerosis, 175(2), 235-243 (2004-07-21)
Since we recently demonstrated that high-density lipoprotein induced human coronary artery endothelial cell (HCEC) tube formation through Ras/Raf/ERK (extracellular-signal-regulated kinase) activation [Arterioscler. Thromb. Vasc. Biol. 23 (2003) 802], it is possible that lipid-lowering agents such as statins, which reduce the
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